99mTc-HMDP是骨的核素显像剂,具有在骨骼中浓集度高和显像清晰的特点.对原发性及继发性的骨肿瘤或骨质代谢病变,由于具有在血和肌肉内的放射性本底低,通过显像都能获得清晰的图像,临床诊断具有重要意义和价值.为此我们进行了HMDP的合成,用99mTc进行标记,并对标记化合物进行放射化学纯度鉴定. HMDP的化学名称为羟甲叉二...
对于ATTR-CM疾病早期(NYHA I-II级)的无创特异性诊断,目前文献报道可使用99mTc标记的骨显像剂(包括99mTc-PYP、99mTc-DPD和99mTc-HMDP)进行心脏闪烁显像。在既往涉及疑似CA患者的研究中,血液和尿液检测除外单克隆免疫球蛋白病后,闪烁显像2-3级诊断...
锝药用于骨显像剂主要有两大类——99mTc标记的磷酸盐和膦酸盐。前者因骨显像质量差而少用于骨显像;后者在体内稳定、血液清除率快、骨组织摄取迅速、靶本比高,是理想的骨显像剂,常用的有99mTc-MDP和99mTc-HMDP(羟基亚甲基二膦酸盐),其中又以99mTc-MDP使...
Bevan JA, Tofe AJ, Benedict JJ, Francis MD, Barnett BL (1980) Tc-99m HMDP (hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. II. Comparison of Tc-99m hydroxymethylene diphosphonate (HMDP) with other technetium-labeled bone imaging agents in...
Accumulation with bone scintigraphy using technetium-99m hydroxymethylene diphosphonate (Tc-HMDP) in 68 cases with radiographically or pathologically verified soft tissue tumor was examined. Radiographical or histopathologic diagnoses of the 68 cases included; 14 lipomas, 11 liposarcomas, 11 neurinomas...
骨显像是临床有价值的核医学检查项目.HMDP(Hydroxymethylene Diphosphonate)是最近发现的一种较好的二膦酸盐类骨显像剂. 我室与核药学研究室联合研制成功了HMDP药盒,并在大白鼠体内做了99mTc-HMDP,99bTc-MDP,99Tc-PYP分布比较,在家兔体内做了99mTc-HMDP,99mTc-MDP血清除率,尿排泄率,显像质量的自身对照.关键词:HMDP...
(对于99mTc-DPD和99mTc-HMDP显像,也有静脉内注射铁剂后心肌摄取假阳性的病例报告。) 99mTc-PYP显像0-1分假阴性可能包括:淀粉样沉积物量不足、肋骨骨折、瓣膜/瓣环钙化、近期心肌梗死(<4周)、成像时机过早或过晚、对99mTc-PYP灵敏度较低的突变类型(Ser77Tyr或Phe64Leu),将心肌摄取诊断为血池摄取。
The uptake of 99mTc-HMDP in normal bone (B/S) was significantly higher than that of MDP at 2 and 3 h, but there were no significant differences between the two compounds with regard to the M/S or M/B or M/B ratios. The M/B of HMDP at 2 h was not significantly different from ...
[8]Flores LG,Nagamachi S,Jinnouchi S,et al.Relationship between extraosseous accumulation in bone scintigraphy with99mTc-HMDP and histopathology[J].Nucl Med Commun,1998,19(4):347-354. [9]王云雅,邓敬兰,王胜军,等.99mTc-MDP骨闪烁显像骨外放射性异常浓聚原因分析[J].现代肿瘤医学,2008,16(10):176...
Tc-hydroxymethylene diphosphonate (HMDP) bone scintigraphy revealed multi-uptakes in the bilateral upper and lower limbs, nearly extended along longitudinal bone cortices. These were consistent with sclerosing dysplasias on bone X-ray of forearms and a tibia.关键词:...