Moreover, the use of CMP-Neu5,9Ac2 has been shown for several sialyltransferases and is exploited for chemo-enzymatic synthesis of 9-O-acetylated sialosides56. In vivo, the efficient and selective usage of CMP-Neu5,9Ac2 may rely on a physical interaction between CASD1 and specific ...
a key parameter to achieve efficient enhancement of binding affinities with receptors43,44(Fig.4). To build the targeted glycoclusters, two clickable sialic acid derivatives1(9-OH) and2(9-O-Ac) were prepared first (Fig.4) and then clicked to the four central scaffolds mentioned above. Thank...
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Chemoenzymatic synthesis of Neu5Ac9NAc-containing α2–3- and α2–6-linked sialosides and their use for sialidase substrate specificity studiesdoi:10.1016/j.carres.2017.09.0039-N-acetyl sialic acid9-O-acetyl sialic acidChemoenzymatic synthesis...
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9. AIDS IN THE INTENSIVE CARE UNIT 161 Survival following hospital admission among 568 HIV-infected individuals with PCP stratified by development of respiratory failure (ARF) 100 90 ·E=.Sb>O 80 70 60 Cf) 50 -:=:OJ 40 OJ 30 ~ 20 10 PCP patients without ARF (n;::S30) • PCP ...
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