Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concentrations of 7-DHC are cytotoxic to developing neurons by favouring lipid ...
7-Dehydrocholesterol (7-DHC) is the substrate of 7-dehydrocholesterol reductase (DHCR7) in the cholesterol synthesis pathway. Keratinocytes in human skin possess the enzymes necessary for cholesterol synthesis but are also responsible for vitamin Dsynthesis from 7-DHC by exposure to UVB irradiation....
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme
CAS号: 9080-21-1 英文名: 7-dehydrocholesterol reductase 英文别名: 7-dehydrocholesterol reductase 中文名: 7-dehydrocholesterol reductase 中文别名: CBNumber: CB31369963 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 2 7-dehydrocholesterol reductase化学性质 ...
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英文名称:Recombinant 7-Dehydrocholesterol Reductase (DHCR7) 英文同义词:Recombinant 7-Dehydrocholesterol Reductase (DHCR7) CAS号: 分子式: 分子量:0 EINECS号: 信息错误报告 您的Email: 按国家浏览Recombinant 7-Dehydrocholesterol Reductase (DHCR7)国外供应商中国供应商 ...
Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression. DHCR7 deficiency or treatment with the natural product 7-dehydrocholesterol (7-DHC) could specifically promote phosphorylation of IRF3 (not TBK1) and enhance type I ...
A sensitive assay for 5α-reductase was introduced which is capable of detecting at least 0.2 U of activity per sample. The assay was used in developing a ... B Houston,GD Chisholm,FK Habib - 《Journal of Steroid Biochemistry》 被引量: 80发表: 1985年 Catechol estrogen formation by brain...
7-Dehydrocholesterol reductase (DHCR7) is the terminal enzyme of cholesterol synthesis in the Kandutsch-Russell pathway, converting 7-dehydrocholesterol (7DHC) to cholesterol. In the absence of functional DHCR7, accumulation of 7DHC and a lack of cholesterol production leads to the devastating ...
7-dehydrocholesterol reductase (DHCR7) is the terminal enzyme of cholesterol synthesis in the Kandutsch-Russell pathway, converting 7-dehydrocholesterol (7DHC) to cholesterol. In the absence of functional DHCR7, accumulation of 7DHC and a lack of cholesterol production leads to the devastating ...