7 oxoDCA(7 氧代脱氧胆酸,7 oxo deoxycholic acid)的结构。 构思思路。 7 oxoDCA 是脱氧胆酸的一种氧化衍生物。我们在了解了脱氧胆酸结构的基础上,考虑其 C 7 位发生氧化反应后的结构变化。脱氧胆酸与胆酸结构有相似之处,但 C 12 位没有羟基。那么 7 oxoDCA 就是在脱氧胆酸的基础上,C 7 位的羟基被氧化...
Interestingly, 7-oxo-DCA promotes cancer cell growth, while isoDCA suppresses it. Moreover, 7-oxo-DCA promotes whereas isoDCA inhibits the proliferation of intestinal stem cells in organoids derived from WT and APCMin/+ mice, as well as in patient-derived colon cancer organoids. The APCMin...
3), resulting in the formation of 7-oxoDCA. This is an independent process from 7-DH-ion and the product cannot be 7-DH-ed. Fig. 3 In vitro transformation of cholic acid. The 7-dehydroxylation of CA was tested in (A) Clostridium scindens ATCC 35704, (B) C. scindens VPI 12708 and...
石胆酸 (LCA) 衍生物直接影响 CD4+ T 细胞(3-oxoLCA 和 isoalloLCA) 3-oxoLCA通过直接结合转录因子 RORγt 抑制 Th17 细胞分化,而isoalloLCA增强 Treg 细胞分化,证实肠道微生物群可能控制宿主免疫反应。 对于肝内胆管癌,观察到甘熊去氧胆酸和牛磺脱...
Concrement A; CoponylE 50(Y8); Coponyl PH 50T; Craymul 1309; Craymul 2322; Crodafix 18-15-000;CustomBond MPA 11; D 50; D 50 (polymer); D 50C; D 50H; D 50M; D 50S; D 51C; DB48/4S; DC 20F; DCA 70; DF 48/5S; DF 48/5SL; DF 51-10C; DF 51/10S; DF 51/15B;...
原文见链接 Energy Metabolism and Metabolic Targeting of Neuroblastoma - ScienceDirect 本篇讲神经母瘤(NB)的潜在治疗方案:糖酵解抑制法3-溴-2-氧代丙酸-1-丙酯3-溴-2-氧代丙酸-1-丙酯 3-Bromo-2-oxopropio…
(hydroxymethyl)-10,24,31,33-tetramethyl-13-oxo-28-phenyl-4,12,27,29,32-pentaoxaoctacyclo[26.3.1.119 ,22.01,8.02,26.03,5.07,11.025,30]tritriaconta-14,16-dien-18-yl 3-methylbutanoate; Butanoic acid, 3-methyl-, (2S,4S,4aS,5R,7R,10S,11R,12Z,14E,17aS,18S,20R,20aS,21S,21aR,22...
CAS No. 4246-51-9 Chemical Name: 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE Synonyms 4,7,10-Trioxatridecane-1,13-diamine;DIETHYLENE GLYCOL BIS(3-AMINOPROPYL) ETHER;q19262;DCA 221;Bis-NH2-C1-PEG3;PROTAC Linker 24;POLYGLYCOLDIAMINE;di(3-aminopropyl)digol;BONDLINE 6175 ADHESIVE;Polyglycoldiamine (...
Gold 3221 SH 0 Dex 18 Spells: 13 memorised, 4 levels left Res.Fire : + . . See Invis. : + a - +7,+1 dagger "Thaecosm" {speed, rF+ rC+ St Res.Cold : + . . Warding : . . h - +4 robe of Night {+Inv MR SInv Stlth++} ...
stdin copy Standard input is empty stdout copy a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt...