研究团队构建了SKOV3、ES-2荷瘤鼠和松节油诱导的炎症模型,将制备的双靶点分子探针68Ga-RGD-NGR经尾静脉注射至小鼠体内后进行 PET/CT显像,24h后进行18F-FDG PET/CT显像,比较两种示踪剂的体内显像表现。腹腔种植SKOV3、ES-2细胞(5×...
目的: 1,以CD13为靶点,合成新的双功能螯合剂NOTA联接的NGR环肽单体和二聚体,并用68Ga标记,为靶向肿瘤血管生成的PET显像提供新的方法.通过肽结构设计,改善前期工作中存在的肝脏高摄取现象. 2,建立本实验室条件下68Ga标记肽的最优化条件和流程,为今后的标记工作和发展自动化标记奠定基础. 3,评估68Ga-NOTA-G3-...
J. Tillmanns, M. Schneider, D. Fraccarollo et al., "PET im- aging of cardiac wound healing using a novel [68Ga]-labeled NGR probe in rat myocardial infarction," Molecular Imaging and Biology, vol. 17, no. 1, pp. 76-86, 2015....
在甄妮生活的那个年代,没有实力的歌手是注定会被淘汰的,只有你的实力足够的出众,你才有可能被大家喜欢。 如今的甄妮已经是68岁的年纪了,但是她依旧那么迷人,虽然如今的港媒经常报道她频繁的换男友,但是每当一提到她的亡夫时,她都是一口长叹继而答到:“我最爱的那个人已经不在了。” 打开网易新闻 查看精彩图片 ...
目的定量对比18F-FDG及新生血管靶向探针68Ga-NGR对高分化肝癌裸鼠模型的micro.PET/CT显像效果.方法以CDl3+的SMMC-7721肝癌细胞及裸鼠模型作为实验组,CDl3+的HT-1080纤维肉瘤细胞及裸鼠作为阳性对照,以及CDl3-的HT.29直肠癌细胞及裸鼠模型作为阴性对照.用Westernblot检测CD13及葡萄糖-6-磷酸酯酶(G6Pase)在3种肿瘤...
In this study, we evaluated our previously developed, αvβ3 and CD13 dual-targeted 68Ga-NGR-RGD in 8 different subcutaneous and orthotopic tumor models.Xiaoying LvXiangming SongYu LongDexing ZengYongkang GaiXiaoli LanJournal of Nuclear Medicine...
The contrast of 68Ga-NGR-RGD imaging of SKOV3 tumor was greater than that of 18F-FDG imaging at both 30min and 1h post injection. Significantly higher tumor-to-muscle ratios (T/M) and tumor-to-liver radios (T/L) were recorded in 68Ga-NGR-RGD PET images than in 18F-FDG PET images...
68 Ga-labeled cyclic NGR peptide for microPET imaging of CD13 receptor expression. Molecules 19, 11600-11612, doi:10.3390/molecules190811600 (2014).Shao Y, Liang W, Kang F, Yang W, Ma X, Li G, et al. 68 Ga-labeled cyclic NGR peptide for MicroPET imaging of CD13 receptor ...
NGRPET/MRI imagingAminopeptidase N (APN/CD13) plays an important role in neoangiogenic process in malignancies. Our previous studies have already shown that68Ga-labelled NOTA conjugated asparagine-glycine-arginine peptide (c[KNGRE]-NH2) specifically bind to APN/CD13 expressing tumors. The aim of...
68 Ga-labeled cyclic NGR peptide for microPET imaging of CD13 receptor expression. Molecules 19, 11600-11612, doi:10.3390/molecules190811600 (2014).Shao Y, Liang W, Kang F, Yang W, Ma X, Li G, et al. 68 Ga-labeled cyclic NGR peptide for MicroPET imaging of CD13 receptor ...