The prodrugs are conjugates that can require the cooperation of multiple enzymes in the kidney to release 6-mercaptopurine or 6-thioguanine, or can selectively release 6-thioguanine. The prodrugs have the formula: wherein R1 is H or NH2, x is 1 or 2 and R2 represents various carboxylic ...
Aim Erwinia amylovora is the causal agent of fire blight, a devastating disease of apples and pears. This study determines whether the E. amylovora guanine-hypoxanthine transporter (EaGhxP) is required for virulence and if it can import the E. amylovora produced toxic analogue 6-thioguanine...
Synthesis of rac -2-Cyano-1-methyl-3-[2-[(4,5,6,7-tetrahydro-4-benzimidazolyl)thio]ethyl]guanidin, a Conformationally Restricted Cimetidine 1 Unmatched element: w:note Analogue The physiological actions of histamine ( 1 ) are mediated by at least two classes of receptors. A short ...