6-Thio-dG详情 评价(0) 货号:ajci8628 CAS:789-61-7 别名:6-巯基-2'-脱氧鸟苷,β-TGdR; 6-Thio-2'-Deoxyguanosine 分子式:C10H13N5O3S 分子量:283.31 纯度:>98% 溶解度:≥ 62.5mg/mL in DMSO 储存:4°C, protect from light 库存:现货 ...
本研究以非小细胞肺癌为研究对象,对6-Thio-dG介导的辐射抗性机制进行了探究,发现6-Thio-dG通过促进端粒染色体的不稳定和抑制损伤的DNA的修复增强非小细胞肺癌的辐射敏感性.多靶点药物联合辐射治疗可能是未来癌症的治疗的一种新策略.中国科学技术大学魏楠中国科学技术大学...
英文名称: 6-THIO-DG CEP 英文同义词: 6-THIO-DG CEP;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-6-S-(2-cyanoethyl)-2'-deoxy-6-thio-N-(2,2,2-trifluoroacetyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];6-(2-Cyanoethylthio)-2'-deoxy-5'-O-DMT-N2-trifluoroacetyl...
6-Thio-dG 商品别名: 6-巯基-2'-脱氧鸟苷 CAS号码: 789-61-7 分子式: C10H13N5O3S 分子量: 283.31 存储条件: 密封保存 加入收藏 | 推荐奖励 | 产品定制 | MSDS文件 商品货号商品规格品牌名称商品价格库存数量购买数量加入购物车 HXB005180-25MG 25毫克,纯度98% 深试 ￥646元 1 加入购物车 HXB005...
6-[(Cyanoethyl)thio]-7-deaza-dG (pac) CE-phosphoramidite 中文名: 中文别名: CBNumber: CB910092924 分子式: 分子量: 0 MOL File: Mol file 6-[(Cyanoethyl)thio]-7-deaza-dG (pac) CE-phosphoramidite化学性质 安全信息 6-[(Cyanoethyl)thio]-7-deaza-dG (pac) CE-phosphoramidite性质、用途与生产工...
1、6-Thio-2'-Deoxyguanosine物理参数: 常用名 6-巯基-2'-脱氧鸟苷 英文名 6-Thio-2'-Deoxyguanosine CAS号 789-61-7 分子量 283.307 密度 2.0±0.1 g/cm3 沸点 709.1±70.0 °C at 760 mmHg 分子式 C10H13N5O3S 熔点 无资料 闪点 382.6±35.7 °C 2、6-Thio-2'-Deoxyguanosine物理化学性质: ...
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In addition, 6-thio-dG pretreatment effectively increased 纬-ray irradiation induced telomere dysfunction (P<0.05), resulting in disruption of chromosome stability and inhibition of the ATM pathway, thereby impairing genomic DNA and telomeric DNA repair, which was closely associated with enhanced drug-...
TERT silencing or treatment of NRAS-mutant melanoma with the telomerase-dependent telomere uncapping agent 6-thio- 2'-deoxy-guanosine (6-thio-dG), led to rapid cell death, along with evidence of both telomeric and non-telomeric DNA damage, increased ROS levels, and upregulation of a ...
The present disclosure provide for methods of using 6-thio-2'-deoxyguanosine (6-thio- dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are ...