英文别名: PFKL (Phosphofructokinase, Liver, PFK-B, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B, Phosphohexokinase)中文名: 中文别名: CBNumber: CB04952060 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 PFKL (Phosphofructokinase, Liver, PFK-B, 6-...
The complex nature of the brain 6-phosphofructo-1-kinase isozymes was examined by elution with a discontinuous gradient from QAE (quaternary aminoethyl)-Sephadex. In the first wash (150 mM NaCl), where the rat muscle 6-phosphofructo-1-kinase isozyme (M4) eluted, about 40% of the total brai...
3 kinase; PFK, 6-phosphofructo-1-kinase; F6P, fructose-6-phosphate; F1,6BP, fructose-1,6-bisphosphate; F2,6BP, fructose-2,6-bisphosphate. .elsevier/locate/ymgme Available online at .sciencedirect Molecular Genetics and Metabolism 92 (2007) 364–370 It has been shown that 5-HT enhances...
Recently, we demonstrated that 6-phosphofructo-1-kinase (PFK; phosphofructokinase; ATP:D-fructose-6-phosphate-1-phosphotransferase; EC 2.7.1.11), the key regulatory enzyme of the glycolytic pathway and a CaM-binding protein, is regulated by CaM, which induces dimerization of PFK from tetramers ...
The allosteric effects of various inositol biphosphate (InsP2) isomers and other inositol phosphates, of glycerophosphoinositol phosphates (GroPInsPx) and of phosphoinositides (PtdInsPx) on muscle-type 6-phosphofructo-1-kinase (PFK) were investigated. The binding of these substances to PFK was indirec...
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The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase (Pfk-1). PFKFB3 is overexpressed in human...
The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are
(HIF)1α and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) signaling pathways, are unknown. Here, we demonstrate that in NHPs, amylin deposition in heart failure (HF) contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. This was confirmed in ...