与其他化疗药物相比,硫鸟嘌呤在细胞内的代谢较为复杂。它需要先转化为活性代谢物6-thioguanine核苷酸(6-thioguanosine monophosphate,TGMP),然后与DNA结合,从而干扰DNA的合成和修复,最终导致癌细胞死亡。 3.硫鸟嘌呤的临床疗效 临床研究显示,硫鸟嘌呤在急性淋巴细胞白血病的治疗中具有显著的疗效。通过与传统化疗药物的联...
英文名称:6-Thioguanosine-5'-O-monophosphate sodium salt CAS:74686-78-5 卡博森斯化学科技 (苏州) 有限公司 联系电话:+86 (512) 6260-5585 电子邮件:sales@carbosynth.com CB指数:50 网址:www.carbosynth.cn 相关信息:产品目录(6532)用户评价(1)
Methods: A novel, highly sensitive assay was established to measure levels of TGTP and its precursors 6-thioguanosine monophosphates and 6-thioguanosine diphosphates (TGDP) in red blood cells from 50 CD patients. The results were correlated with clinical outcome. Results: TGTP levels could be ...
Chemical Name CAS Number 74686-78-5 Mol. Formula C10H13N5O7PS.Na Mol. Weight 401.27 Qty 1 1mg Qty 2 2mg 下一个:a-D-Thiomannose sodium salt上一个:2-Thiocytidine 联系我们 电话:021-60498804 邮箱:info@e-biochem.com 地址:上海市徐汇区漕溪路258弄27号航星商务楼2-404 ...
In addition, within 10-min incubation, whereas the overall amount of 6-TG taken up by LoVo cells is approximately 3 times greater than that incorporated in 6-TGr cells, no appreciable amount of thioguanosine monophosphate is formed in either cell type. REFERENCES Top of page Abstract MATERIAL ...
英文别名: 6-T-5′,-GMP;6-Thio-5'-guanylic acid disodium salt;6-Thioguanosine-5'-O-monophosphate sodium salt 中文名: 6-硫代-5'-鸟苷酸二钠盐 中文别名: 鸟苷酸二钠盐;6-硫代-5'-鸟苷酸二钠盐 CBNumber: CB02562193 分子式: C10H14N5Na2O7PS** ...
酸(6-thioinosinemonophosphate,TIMP)。随后TIMP在次黄嘌呤核苷一磷酸脱氢酶 (inosinemonophosphatedehydrogenase,IMPD)和鸟嘌呤一磷酸合成酶(guanine monophosphatesynthetase,GMPS)作用下被转化为硫鸟嘌呤核苷一磷酸(thioguanosine monophosphate,TGMP),TGMP在磷酸激酶的作用下形成6-硫鸟嘌呤核苷二磷酸(6 -thioguanosinediphosph...
Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the ...
NUDT15 enzyme inactivates the active thiopurine metabolite thioguanosine triphosphate (TGTP) by converting TGTP to thioguanosine monophosphate (TGMP). The genetic variations in the NUDT15 gene result in the poor metabolism of thiopurines and are associated with 6-MP toxicity [11]. Apart from drug-...
three metabolic pathways: The first is through the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), then into thioinosine monophosphate (TIMP) and, subsequently, into 6-thioxanthosine-5-monophosphate (TXMP) and active metabolite 6-thioguanosine nucleotides (mono-, di-, and triphosphate)....