(14) The patent claimed a method of administering 6-thioguanine to a patient and then determining the level of 6-thioguanine. A biotechnology dilemma: patent your inventions (if you can) or keep them secret (43) Nodular regenerative hyperplasia has been associated with a variety of drugs, incl...
6-thioguanine: a new old drug to procure remission in inflammatory bowel disease. Intern Med J. 2003;33(1- 2):44-6.Cheung TK, Florin TH. 6-thioguanine: a new old drug to procure remission in inflammatory bowel disease. Intern Med J 2003; 33: 44-46...
The ideal dose for a patient is usually calculated by weight, but the rate of metabolism of azathioprine to its active metabolite 6-thioguanine (6TGN) varies between individuals. In addition, therapy may be limited by non-compliance, side effects or relapse of disease while on treatment. This...
Cell populations resistant to high doses (30 μM) of 6-thioguanine (6-TG, 6-TGr cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSα, is resistant to low doses of 6-TG. ...
6-Thioguanine 产品编号:3331447 规格:≥98% CAS NO:154-42-7 包装规格:100 MG,250 MG,500 MG,1 G,5 G 产品类别:进口试剂 品牌:Sigma-Aldrich 优惠价:立即咨询 产品价格查看更多规格... 产品编号包装单位单价(元)国内现货国外库存询价单 3331447100 MG702 ...
The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the inventi
6-thioguanine EV71: Enterovirus 71 BIRC3: Baculoviral IAP repeat containing 3 HFMD: Hand, foot, and mouth disease CC50 : 50% cytotoxicity concentration of compounds IC50 : 50% inhibitory concentration of compounds against virus SI: Selectivity index FDA: US Food and Drug Administration...
6-thioguanine nucleotides (6-TGNindividualization chemotherapyacute lymphoblastic leukemiaThe aim of this study was set up a simplistic but low-cost method for 6-mercaptopurine (6-MP) individualization chemotherapy for Acute Lymphoblastic Leukemia (ALL) children in developing China. The blood samples of...
6-Thioguanine is an immunosuppressive drug, an analogue of guanine, applied to treat acute leukemia and inflammatory bowel disease. Excessive use of 6-thioguanine during clinical treatment may cause side effects. Moreover, providing a dose too low will b
[47,48], the cytotoxicity of TG has been attributed primarily to the aberrant processing of 6-methythioguanine/thymine mispairs. Indeed, in all systems described to date, TG could be shown to be substantially more toxic to MMR-proficient than -deficient cells. In a recent publication, Yan et...