Arylthiazolylimidazole als 5HT3-Antagonisten. Arylthiazolylimidazole as 5HT3 antagonistsArthur Adam NagelJames Patrick RizziTerry Jay Rosen
Therapeutische verwendung von 5-ht3-rezeptor-antagonisten. Therapeutic use of 5-HT3 receptor antagoniststhe 5-ht3 receptor antagonists are useful for treating panic disorder and / or agoraphobia and obsessive psychon u00e9vroses.AZCONA Alberto...
1.van Wijngaarden I, et al. Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. J Med Chem. 1993 Nov 12;36(23):3693-9. 关键词 5 HT3 antagonist 35-HT-3 antagonist 35HT3 antagonist 35-HT3 antagonist 3Related...
lang=en&linkID=SSR00059附表:5-HT3受体拮抗剂的原研药/参比制剂、一致性评价情况中文通用名英文通用名中文商品名英文商品名规格参比制剂/原研药来源通过一致性评价的厂家盐酸昂丹司琼片(1992,FDA)OndansetronHydrochlorideTablets枢复宁Zofran4mg;8mgNovartisPharmaceuticalsCorp(国内未上市)参比制剂目录第七批、第四十一批...
The present invention is directed to new pharmaceutically active compounds with 5-HT3 receptor antagonist activity of Formula I: <CHEM> in which the dashed line denotes an optional double bond; n is 1, 2 or 3; p is 0, 1, 2 or 3; q is 0, 1 or 2; each R<1> is halogen, hydrox...
I nterest in the role of the 5-HT receptors in the control of anxiety first arose when clinical trials revealed an anxiolytic-like effect of the non-selective 5-HT2 antagonist ritanserin in humans1. Since this time a number of preclinical trials have been carried out, the majority of ...
The serotonin (5-hydroxytryptamine, 5-HT) antagonists, which bind at the type 3 receptor (5-HT3 receptor), have been evaluated in several preclinical model
Wie hierin und in den beigefügten Ansprüchen verwendet, beinhalten die Singularformen „ein, eine, einer" und „der, die, das" den Pluralbezug, sofern der Zusammenhang nicht deutlich etwas anderes angibt. Somit beinhaltet beispielsweise eine Bezugnahme auf „einen Antagonisten" mehr...
申请(专利权)人: SANDOZ LTD.;SANDOZ-PATENT-GMBH;SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. 发明人: N Joachim 摘要: Compounds of formula I wherein in free base or acid addition salt form, exhibit serotonin 1D (5-HT)-receptor agonistic activity and are thus useful interalia in the ...
1-BENZYL-5-PIPERAZIN-1-YL-3,4 DIHYDRO-1H-CHINAZOLIN-2-ON-DERIVATE UND DIE JEWEILIGEN 1H-BENZO(1,2,6)THIADIAZIN-2,2-DIOXID UND 1,4-DIHYDRO-BENZO(D)(1,3)OXAZIN-2-ON-DERIVATE ALS MODULATOREN DES 5-HYDROXYTRYPTAMIN-REZEPTORS (5-HT) ZUR BEHANDLUNG VON ERKRANKUNGEN DES ZENTRALEN NERV...