The effect of this mutation on 5-HT2CR was evaluated at the behavioral (social interaction, novelty-suppressed feeding, and 5-HT2CR-induced hypolocomotion tests), the neurochemical, and the cellular (RT-qPCR, mRNA editing, and c-fos-induced expression) levels.Although 5-HTT(-/-) mice ha...
To further examine the function of this receptor, 5-HT2C receptor mutant mice were generated; studies of these animals reveal pleiotropic neurobehavioural effects of the mutation. Three examples are described: (1) Mutants exhibit chronically elevated food intake and the development of an obesity ...
These tests Cognitive deficits induced by Tph2 mutation T Del'Guidice et al 1129 Figure 2 Performances per genotype of Tph2-KI mice in each task of the automated H-Maze. (a, c, and e) Average number of trials (±SEM) needed to reach the criterion of four consecutive successful trials...
Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci 29: 8156–8165. Acosta JI, Thiel KJ, Sanabria F, Browning JR, Neisewander JL (2008). Effect of schedule of reinforcement on cue-elicited reinstatement of ...
The W130A mutation reduced the activity of both 5HT (Figure 3Di and S6) and lorcaserin in the VGV isoform, shifting the logEC50 for 5HT by +1.36 (p < 0.05). It is noted that the right shift in the curve for the VGV-W130A mutation in lorcaserin is so extreme that a complete ...
Nur77andNurr1areorphannuclearreceptorsandmembersoftheNR4Asubfamily.Here,wereportthattheexpressionofhypothalamicNOR1wasremarkablydecreasedinmildlyobeseb-endor-phin-deficientmiceandobesedb/dbmicewiththeleptinreceptormutation,comparedwithage-matchedwild-typemice,whereastherewerenogenotypicdifferencesintheexpressionof...
Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of b-endorphin gene. Int J Neuropsychopharmacol 12:547-552.Nonogaki K, Ohba Y, Wakameda M, Tamari T (2009 a). Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation...
Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of b-endorphin gene. Int J Neuropsychopharmacol 12:547-552.Nonogaki K, Ohba Y, Wakameda M, Tamari T (2009 a). Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation...
The mutation responsible for this fatal disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding the huntingtin protein. Various hypotheses have been put forward to explain the pathogenic mechanisms of mutant hunting,tin-induced neuronal dysfunction and ...
Evaluation of a Cys23Ser mutation within the human 5- HT2C receptor gene: no evidence for an association of the mutant allele with obesity or underweight in children, ado- lescents and young adults. Life Sci 61(1), PL9-16.Lentes KU, Hinney A, Ziegler A, Rosenkranz K, Wurmser H, ...