Allelic variation in the serotonin 5-HT2c receptor gene and migraine. Neuroreport 1997, 8: 2651–2653.Burnet PW, Harrison PJ, Goodwin GM, Battersby S, Ogilvie AD, Olesen J, Russell MB (1997) Allelic variation in the serotonin 5-HT2C receptor gene and migraine. Neuroreport 8:2651-3...
schizophrenia, panic attacks, melancholia, appetite disorders, obesity, insomnia, pain, psychotic disorders, epilepsy, diabetes, Parkinson's disease, senile dementia, various disorders associated with normal or pathological ageing, migraine, memory loss, Alzheimer's disease, and in cerebral circulation dis...
The 5-HT2C receptor subtype has been implicated in a wide variety of conditions including obesity, anxiety, depression, obsessive compulsive disorder, schizophrenia, migraine and erectile dysfunction and as a consequence has received considerable attention as a target for drug discovery. Here we review...
R2, R3, or R4 are not hydrogen; which are 5HT2C receptor agonists useful for the treatment of disorders involving the central nervous system such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, type II diabetes, and epilepsy...
A trend toward a significant effect of the 12-repeat hSERT allele as a risk factor for migraine with aura versus unrelated controls was observed. Conclusion.—Our data do not support the involvement of 5-HT 1B/1D and 5-HT 2C receptor gene polymorphisms in migraine with aura, yet do ...
An investigation of the 5-HT2C receptor gene as a migraine candidate gene. Am J Med Genet B Neuropsychiatr Genet 2003;117(1):86-9.Johnson MP,Lea RA,Curtain RP. An investigation of the 5-HT2C receptor gene as a migraine candidate gene[J].Am J Med Genet B Neuropsychiatry Gent,2003,(1...
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). This receptor has been used as a target for developing drugs to treat migraine and obesity....
(57) For example, obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, II diabetes mellitus and [summary] The present invention is related to the central nervous system such as epilepsy is a useful 5-HT receptor agonist for the ...
The compounds exhibit enhanced 5HT2C? receptor antagonist activity profile. 5HT2C receptor antagonists are believed to be of potential use in the treatment of CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimer's disease, sleep disorders, feeding ...
US5753663 1996年9月24日 1998年5月19日 Syntex (U.S.A.) Inc. Pyrimidine derivativesUS5753663 1996年9月24日 1998年5月19日 Syntex (U.S.A.) Inc. 5ht2c antagonist, useful for treating anxiety, pain, obsessive compulsive disorder, alcoholism, depression, migraine, sleep disorder, anorexia ...