Mutations in 5-HT2A are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mut... Show More ...
The forced swim test is a common animal model for testing the effectiveness of antidepressant medications. This test shows that effective antidepressant treatments decrease overall immobility time. Using the forced swim test, a 5-HT2A antagonist, MDL 100907, was used to determine if blocking this ...
MF C20H21F3N4O MW 390.40 Purity: 99% Soluble in DMSO Description A 5-HT1A receptor full agonist with 5-HT2A receptor antagonistic activity; It was initially investigated as an potential antidepressant, however, it is currently under clinical trial for the potential treatment of female sexual dysf...
Serotonin 5- 'antidepressant-like' action between a highly selective 5-HT-2A antagonist (M100907) and the SSRI fluoxetine on DRL 72-s behavior. Soc Neurosci Abstr 27: 975.8. HT1D receptors. Ann NY Acad Sci 600: 168–181. Marek GJ, Wright RA, Gewirtz JC, Schoepp DD (2001b). A ...
A 5-HT1A receptor full agonist with 5-HT2A receptor antagonistic activity; It was initially investigated as an potential antidepressant, however, it is currently under clinical trial for the potential treatment of female sexual dysfunction. References: E Jolly et al. Design of Phase III pivotal...
Trazodone Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders. AI解读 关联靶点(人) 关联靶点(其它种属) 作用机制 到第页 名称和识别符 化学和物理性质 ...
(GPCR). 5-HT2ARs appear to primarily mediate psychedelic experiences supported by evidence that the 5-HT2AR antagonist ketanserin attenuates subjective effects of psilocybin and LSD in humans7,8. Psychedelics have also been studied in preclinical behavioral models, including the head-twitch response ...
(AMSG). Both selective serotonin reuptake inhibitors and AMSG exert antidepressant action through the serotonin (5-HT) system as reuptake inhibitors. Amesergide differs from SSRIs in that it is also a highly selective 5-HT antagonist, which may in part account for differences in cerebral blood ...
(HPA axis). Thus, local administration of a 5-HT2Areceptor antagonistdecreases the hypothalamic hormonal response to sexual stimuli, while a 5-HT2Creceptor antagonist increases it(Popova and Amstislavskaya, 2002). Hippocampal 5-HT2Areceptor activation was found to increase working memory efficiency(...
A multiple regressions analysis indicated that 81% of the variance in the ability of a given antagonist to block the mCPP stimulus could be predicted on the basis of its affinity for 5-HT2A and 5-HT2C receptors. It is concluded that the stimulus effects of mCPP are mediated predominantly ...