These findings suggest that 5-HT 1A receptor activation may promote oligodendrogenesis and myelination via an ERK/CREB/BDNF signaling pathway in the hippocampus and reduces abnormal emotionality due to maladaptation to excessive stress. Copyright 2021. Published by Elsevier Ltd....
5-HT1Areceptoractivationreducesfear-relatedbehaviorfollowingsocialdefeatinSyrianhamstersLaurenR.Bader⁎,JosephD.Carboni,CodyA.Burleson,MatthewA.Cooper..
Moreover, RNA-seq analysis found that tandospirone modulated the RTT phenotype partially through the CREB1/BDNF signaling pathway in our mouse model. Respiratory disorders are prominent and one of the most disturbing features of RTT. This phenotype was faithfully mimicked in our mouse model of ...