胞嘧啶脱氨基酶(CD)是一种存在于细菌和真菌中的酶,能将5氟胞嘧啶(5—FC)转化为5氟尿嘧啶(5—FU),前者对细胞无影响,后者会抑制DNA和RNA合成使细胞死亡,可用于杀伤肝癌细胞治疗肝癌。研究人员将5—FU与宫颈癌细胞膜抗原(CA125)的特异性抗体(OC125)结合制备抗体偶联药物(过程如下图所示)。某种腺病毒能特异性的...
然后再进一步通过尿嘧啶磷酸化转移酶FUR1对5-FU进行加工,从而抑制DNA和蛋白质的合成。耐药性在大多数真菌病原体通过FCY1、FCY2和FUR1的功能突变缺失可以介导对5-FC的耐药性。然而,隐球菌中对5-FC产生抗性的原因却未详细探究。 近日发表在《Nature Communications》“5-fluorocytosine resistance is associated with...
4X4 4X4X4 4YC 4YFN 4Z 5 5-AED 5-ASA 5-Br-dUMP 5-D 5-FC 5-FU 5-HT 5-HTP 5-HTPD 5-HTTLPR 5-MEO-DIPT 5-MEO-DMT 5-MEODMT 5-MNBA 5-TMRIA 5/3 50 500 500LP 501 502 503 504 505 506 507 509 50C 51 51/50 ▼
产品名称：5-FU-miR-15a 状态：固体/粉末/溶液 产品规格：mg 保存：冷藏 储藏条件：-20℃ 储存时间：1年 用途：科研 温馨提醒：仅供科研，不能用于人体实验 产品名称：PPT-5-氟尿嘧啶 状态：固体/粉末/溶液 产品规格：mg 保存：冷藏 储藏条件：-20℃ 储存时间：1年 用途：科研 温馨提醒：仅供科研，不能用于...
背景Cytosine 脱氨基酶(CD ) 在 CD/5-FC 基因治疗把 5-fluorocytosine (5-FC ) 变换成 5 氟尿嘧啶(5-FU ) ,没有 uracil phosphoribosyltransferase (UPRT ) , 5-FU 将主要被变换成无毒的丙氨酸.UPRT 催化 5-FU 的变换到 5-fluorouridine monophosphate,直接,杀死表示 CD::UPRT 它装壁板圩并且经由旁观者...
Nature 502, 472-479. Song, C.X., Szulwach, K.E., Dai, Q., Fu, Y., Mao, S.Q., Lin, L., Street, C., Li, Y., Poidevin, M., Wu, H., et al. (2013). Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 153, 678-691....
To fix this problem, we created a corrective replicative plasmid expressing the pyrR gene, which was shown to restore the 5FU sensitivity of the strain. Furthermore, in order to avoid the occurrence of the problem observed with the CAB1060 strain, a preventive suicide plasmid, pCat-upp-pyrR...
25plmt 25CM | Plymouth S2 -current- 24Presión Baja 24Salida de balón: vs Presión alta 24Presión Alta 24Salida de balón: vs Presión Baja 25plymouth season 2 24plymouth argyle 24Playmouth Argyle B 25Green army 25Plymouth Argyle
Sean Fusire (Sean Sheunesu Fusire, born 31 May 2005) is a British footballer who plays as a center midfield for British club Carlisle United, on loan from Sheffield Wednesday. In the game FC 25, his overall rating is 54.
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