Purification and characterization of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol 27-hydroxylase from female rat liver mitochondria. J. Biol. Chem. 263: 18138-18142.Okuda, K., O. Masumoto, and Y. Ohyama, 1988. Purification and characterization of 5-cholestane-3␣,7␣,12␣-...
Cholestane-3beta,5alpha-diol-6-one was identified using thin-layer and gas-liquid chromatography, infrared spectroscopy, and the spectrum produced by reaction with 65% sulfuric acid. The mixed esters of cholestane-3beta,5alpha,6beta-triol were subjected to basic hydrolysis, and the steroid ...
Compound Cholestane-3.beta.,5.alpha.,6.beta.,26-tetrol - 26-Acetatewith free spectra: 1 MS (GC).
Triol increased calcifying nodule formation, calcium deposition, ALP activity, and apoptosis of nodular cells in calcifying VSMCs. As determined by 2,7-dichlorofluorescein fluorescence, Triol induced the generation of reactive oxygen species (ROS) in calcifying VSMCs dose- and time-dependently. Triol...
The partially purified enzyme was active for both 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol and 5 beta-cholestane-3 alpha, 7 alpha-diol. That the enzyme activities for these substrates were not due to two different enzymes but to the same active site of a single enzyme protein ...
7 alpha12 alpha-trihydroxycoprostaneNiemann-Pick type C (NPC) is a progressive neurodegenerative disease characterized by lysosomal/endosomal accumulation of unesterified cholesterol and glycolipids. Recent studies have shown that plasma cholestane-3,5,6-triol (CT) and 7-ketocholesterol (7-KC) could...
EpilepsyOxysterolCholestane-3 beta-5 alpha-6 beta-triolVoltage-gated sodium channelsImbalance of excitation and inhibition in neuronsLengSunTiandongSunZhangSunJingxiaSunHaiyanSunSunSunHuanhuanSunQiuSunPengxinSunZhuSunSteroids: An International Journal
The invention reveals that endogenous cholesterol metabolic product cholestane-3 beta, 5 alpha, 6 beta-triol (YC-5) has protection function for neuronal damage caused by cerebral ischemia, ischemia ofspinal cord, epileptic seizure and convulsion and relates to an application of YC-5 in preparation...
6 beta-triolOxysterolsNiemann-Pick type C (NPC) is a neurological disease caused by an intracellular cholesterol accumulation. Cholesterol oxidation product cholestane-3 beta,5 alpha,6 beta-triol (C-triol) serves as diagnostic biomarker for NPC, but its measurement in the routine laboratory remains...
This study was designed to examine whether 13C nuclear magnetic resonance (NMR) spectroscopy can be used to differentiate between the 25R and 25S diastereoisomers of 5 beta-cholestane-3 alpha, 7 alpha, 26-triol, a key intermiediate in the biosynthetic pathway of chenodeoxycholic acid. Chemical...