Ronidazole and dimetridazole, two important veterinary drugs, were found to react readily in the presence of cysteine, under neutral aqueous conditions, leading to the formation of 5-S-cysteinyl-1-methylimidazole-2-methanol carbamate and 5-S-cysteinyl-1,2-dimethylimidazole respectively through ...
Physicochemical considerations in the formulation development of silicone elastomer vaginal rings releasing 5-nitroimidazole drugs for the treatment of bacterial vaginosisAuthor(s): Xinyu Zhao , Peter Boyd , Yahya H. Dallal Bashi , Clare F. McCoy , R. Karl Malcolm Publication date Created: ...
1-Methyl-5-nitroimidazole is used in the synthesis of new 5-nitroimidazoles as potential antibacterial drugs via VNS procedure. 1-METHYL-5-NITROIMIDAZOLE Preparation Products And Raw materials Raw materials4. MSDS2.Hazard identification 2.1 Classification of the substance or mixture Acute toxicity -...
To enter the brain, drugs must pass through the endothelial cells of the capillaries of the central nervous system (CNS) or be actively transported. Lipid-soluble drugs readily penetrate into the CNS because they can dissolve in the membrane of the endothelial cells (Page 554 of Lippincott's ...
Rapid synthesis of new 5-nitroimidazoles as potential antibacterial drugs via VNS procedure. were prepared by reacting four chloromethylaryl sulfones with 5‐nitroimidazole derivatives via a vicarious nucleophilic substitution (VNS) of hydrogen reaction... Maxime D. Crozet,Vincent Rémusat,Christophe Curti...
Design of hypoxia-targeting drugs as new cancer chemotherapeutics. The tumor microenvironment is now recognized as a major factor that influences not only the response to conventional anti-cancer therapies but also helps d... Hideko,Nagasawa,Yoshihiro,... - 《Biological & Pharmaceutical Bulletin》 被...
Synthesis and antiprotozoal activity of 1-(3-chloro-2-hydroxypropyl)-substituted nitroimidazoles - Hoffer, Grunberg - 2011 () Citation Context ...roimidazoles are synthetic drugs. The first 5−nitroimidazole drug to come on the market... M Hoffer,E Grunberg - 《Journal of Medicinal Chemistry...
Drugs Exp Clin Res 11:317–329 CAS PubMed Google Scholar Fernandes PB, Shipkowitz N, Bower RR, Jarvis KP, Weisz J, Chu DTW (1986) In-vitro and in-vivo potency of five new fluoroquinolones against anaerobic bacteria. J Antimicrob Chemother 18:693–701 Article CAS PubMed Google Scholar ...
5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and development of resistance particularly with metronidazole. For the development of new potentially safer derivatives, we investigated new strategies of synthesis: such as Vicarious Nucleophilic ...
new 5-nitroimidazole drugs useful as medicines for the treatment of microbial infections2-(5-Nitroimidazol-2-ylvinyl)thiadiazoles of formula (I) are new: (where R1 is 1-4C alkyl opt. substd. by OH; or 1-4C alkoxy; R2 is H or Me; R3 is H, 1-24C alkyl, opt. substd. phenyl ...