Interestingly, 5‐MTP did not affect IL‐1β or TNF‐α‐reduced EC proliferation. In contrast, 5‐MTP ameliorates IL‐1β‐induced inflammatory cell adhesion and TNF‐α‐reduced EC migration. Taken together, our results suggest an important role of 5‐MTP on EC regeneration after vascular ...
5-Methoxytryptophan (5-MTP)Mouse and cell culture studies suggest 5-MTP could help treat cancer. Further details on the research, next steps and licensing status are discussed in the article.doi:10.1038/scibx.2012.834Abu-Baker, S.Green, R.J.SciBX: Science-Business eXchange...
5-Methoxytryptophan (5-MTP), a 5-methoxyindole metabolite of tryptophan metabolism, was recently shown to suppress inflammatory mediator-induced cancer cell proliferation and migration. However, the role of 5-MTP in vascular disease is unknown. In this study, we investigated whether 5-MTP protects...
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, particularly among older adults. Despite the advent of medical technology, restenosis is still an issue after interventional procedures. Tryptophan metabolite 5-methoxytryptophan (5-MTP) has recently been shown to protec...
ZC-56353-J-5-甲氧基色氨酸(5-MTP)定量检测试剂盒(ELISA) 快递形式 上海茁彩生物科技有限公司 4年 查看详情 ￥50.00/千克 湖北 5-氟-DL-色氨酸(154-08-5) 国产品牌 湖北广奥生物科技有限公司 6年 查看详情 ￥800.00/千克 湖北武汉 5-羟基-L-色氨酸 4350-09-8小分子抑制剂 医药中间体 植物...
5-Methoxytryptophan (5-MTP), an endogenous metabolite of tryptophan, was revealed to block systemic inflammation. However, the specific mechanism by which 5-MTP affects ALI still needs to be clarified. The purpose of this study was to determine whether 5-MTP protected the lung by inhibiting ...
Previous studies have revealed that the endogenous tryptophan metabolite 5-methoxytryptophan (5-MTP) can downregulate cyclooxygenase-2 expression; suppress tumor proliferation, migration, and invasion; and reduce the tumor size. To improve the understanding of the molecular mechanisms involved in the ...
A diagnostic method for inflammatory diseases, and the diagnostic kit used in the method. The diagnostic method includes the use of a novel tryptophan metabolite, 5-methoxytryptophan (5-MTP), as a diagnostic biomarker of inflammation. Specifically, a highly specific competitive ELISA is provided to...
We found that treatment with 5MTP contributed to decreased activation of pro-inflammatory microglia and reduced the generation of inflammatory cytokines, including TNF-伪, IL-1尾, IL-6 and IL-18, by negative regulation of the p38-MAPK signaling pathway and NLRP3/caspase-1 expression. In vivo,...
Consequently, 5-MTP-treated MI rat hearts exhibited lower levels of chemokines and cytokines, namely interleukin (IL)-1尾, IL-18, IL-6, CC motif chemokine ligand (CCL)-2, and CCL5, accompanied by reduced infiltration of CD11b cells and CD4 T cells. Notably, 5-MTP protected against H2O2...