INCHIKEY LJBQRRQTZUJWRC-UHFFFAOYSA-N 别名 1H-ISOINDOLE-1,3(2H)-DIONE, 2-(2,6-DIOXO-3-PIPERIDINYL)-5-HYDROXY-;PHTHALIMIDE, N-(2,6-DIOXO-3-PIPERIDYL)-4-HYDROXY-;5-HYDROXY THALIDOMIDE, (+/-)-;5-HYDROXY THALIDOMIDE 扩展信息 VIP...
英文名称: 5'-HYDROXY THALIDOMIDE 英文同义词: 5'-HYDROXY THALIDOMIDE;cis-5-Hydroxy-3-phthalimidoglutarimide;2-(5-hydroxy-2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione;2-(5-Hydroxy-2,6-dioxo-3-piperidinyl)-;Thalidomide 5-Hydroxypiperidine Impurity;1H-Isoindole-1,3(2H)-dione, 2-[...
Here, we report the structural bases for the SALL4-specific proteasomal degradation induced by 5-hydroxythalidomide, a primary thalidomide metabolite generated by the enzymatic activity of cytochrome P450 isozymes, through the interaction with cereblon (CRBN). The crystal structure of the metabolite-...
N-hydroxythalidomide; N-hydroxythalidomide; N-hidroxitalidomida; 1H-Isoindole-1,3(2H)-dione, 2-(1-hydroxy-2,6-dioxo-3-piperidinyl)-; 1'-HYDROXY THALIDOMIDE; 2-(1-Hydroxy-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 2-(1-hydroxy-2,6-dioxopiperidin-3-yl)-1H-isoindole-1,...
VIP 扩展信息
PROBLEM TO BE SOLVED: To provide an optically active 2-(5-hydroxy-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione derivative which is a thalidomide metabolite and to provide a method for producing the derivative.;SOLUTION: The optically active 2-(5-hydroxy-2,6-dioxopiperidin-3-yl)isoindoline...
The first asymmetric synthesis of (S)- and (R)-5-hydroxythalidomides, one of thalidomide's major metabolites, was achieved using HMDS/ZnBr2-induced imidation as a key reaction. 5-Hydroxythalidomide was found to be configurationally more stable than thalidomide at physiological pH. Stereochemical ...
PROBLEM TO BE SOLVED: To provide a new 3'-fluoro-5'-hydroxythalidomide derivative and an optically active substance thereof. SOLUTION: A 3'-fluoro-5'-hydroxythalidomide derivative represented by general formula [A] (wherein R1is a hydrogen atom, a silyl, alkyl, or cycloalkyl group, etc.;...
PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomidedoi:10.1101/2020.02.28.969071Satoshi YamanakaHidetaka MuraiDaisuke SaitoGembu AbeEtsuko TokunagaTakahiro IwasakiHirotaka TakahashiHiroyuki TakedaTakayuki SuzukiNorio ShibataCold Spring Harbor Laboratory...
As analogs of thalidomide, the 3′-fluoro-5′-hydroxythalidomide derivatives are useful in the treatment of erythema nodosum of Hansen's disease, prurigo, rheumatism, Crohn's disease, graft-versus-host disease, Behcet's disease, myeloma, aphtha ulcer and the like. Further, the 3′-fluoro-5...