5-HTTLPR L Allele Gene may be a Protecting Factor for Eating Disorder -- A Meta-AnalysisObjective: Eating disorders are conditions defined by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and mental health, which ...
promoter region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) commonly reported with two variants: the l (long) allele, linked to increased concentrations of 5-HTT messenger RNA and increased serotonin (5-HT) uptake, and the s (short) allele, associated with decreased 5-HT uptake ...
Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. Eur Arch Psychiatry Clin Neurosci, 2009, 259: 106—113 23 Stifter C, Willoughby M, Towe-Goodman N. Agree or agree to disagree? Assessing the convergence between...
Together, these studies implicate the 5-HTTLPR short allele in poorer memory function in addition to its role in affective processes. However, not all studies have found the s allele to have deleterious effects on cognition.5 Indeed, healthy s carriers have been found to outperform l homozygote...
Methods5-HTT genotype and allele were detected by polymerase chain reaction (PCR) amplification of 76 patients with first episode of MDD and 73 normal controls.Case control method was used to analyze the correlation between different genotypes and the onset, the clinical features, and cognitive func...
Therefore, fewer 5-HTT sites on platelets of depressed patients, and fewer 5-HTT sites in the PFC of suicides, may be because of an association of the short 5-HTTLPR allele with major depression or suicide. Results of studies67-71 disagree regarding an association of the 5-HTTLPR genotype ...
were no significant differences in the frequency of 5-HTTLPR allele between SID, SIVD and control group ( 2 =4.896,P=0.086). Among women, there were significant differences in the frequency of 5-HTTLPR genotypes between SID, SIVD and control group ( 2 =9.735,P=0.045). The frequency...
Met BDNF protects against morphological S allele effects of 5-HTTLPR. Molecular Psychiatry, 13(7), 654.Pezawas L , Meyer-Lindenberg A , Goldman AL , Verchinski BA , Chen G , Kolachana BS , Egan MF , Mattay VS , Hariri AR , Weinberger DR . 2008 . Evidence of biologic epistasis ...
The serotonin transporter-linked polymorphic region 5-HTTLPR is a key genetic regulator of 5-HTT expression in the human brain where the short allele S has been implicated in emotion dysregulation. However, the neural mechanism underlying the association
The final studies have also been subjected to quality assessment using the Joanna Briggs Institute Critical Appraisal Checklist.Results: Preliminary results support the association of the S allele with maladaptive emotional processing and traits linked to depression and anxiety. The maladaptive traits were...