5-HT(PFEIL ABWAERTS)1(PFEIL ABWAERTS)-REZEPTORThe description relates to novel polypeptides which are 5HT1X receptors. The polypeptides are produced by genetic engineering.BACH ALFRED DRUNGER LILIANE DRBIALOJAN SIEGFRIED DRSEEBURG PETER PROF DR...
7-ARYLSULFONAMID-2,3,4,5-TETRAHYDRO-1H-BENZOiD枚AZEPINE MIT 5-HT6 REZEPTOR AFFINIT脛T ZUR BEHANDLUNG VON ZENTRALNERVENSYSTEMERKRANKUNGEN 7-aryl sulfonamide-2,3,4,5-tetrahydro-1H-BENZOiD枚AZEPINE WITH 5-HT6 RECEPTOR AFFINITY FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS...
Tropisetron; Unclassified drug; Article; Cancer; Cancer chemotherapy; Drug mechanism; Drug structure; Drug synthesis; Nausea; Structure analysis; Vomiting; Animals; Antiemetics; Antineoplastic Agents; Cocaine; Humans; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Structure-Activity Relationship; Vomit...
5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, Calkoxycarbonyl, or secondary or tertiary hydroxy substituted Calkyl; ; and R, Rand Rare independently hydrogen or Calkyl; and Ris hydrogen or Calkyl; and their use as pharmaceuticals in ...
5-ht(pfeil abwaerts)1(pfeil abwaerts)-rezeptor 5-HT (arrow abwaerts) 1 (down arrow) receptordoi:DE4041464 A1The description relates to novel polypeptides which are 5HT1X receptors. The polypeptides are produced by genetic engineering.Alfred Dr Bach...
A compound of formula (I) or a salt thereof:wherein:P1 is pyridiyl;P2 is phenyl;A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl;R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, ...
Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT4 receptors. wherein Ak is a C3-C6 alkyl group, and R is a C2-C6 alkyl group, a C3-C6 alkenyl group, a C3-C6 alkynyl group, a C3-C7 cycloalkyl group or a C3-C6 cycloalkylmethyl...
These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.HESTER JACKSON B JRROGERS BRUCE NJACOBSEN E JONENNIS MICHAEL DALTONACKER BRAD AVANDER VELDE SUSAN LFRANK KRISTINE E
Substituierte indoline als 5-ht-rezeptor liganden Substituted indoline as a 5-HT receptor ligandsThe present invention provides pharmaceutically active compounds of formula I as described herein useful for the treatment of diseases or disorders of the central nervous system....
Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden Hexahydroazepino (4.5 g) indoles and -indoline as 5-HT receptor-ligandJian-Min FuKay Jeanette MORRISGlenn Arthur ROMERO