Model simulations also provide evidence that 5-methylTHF (and not 5fTHF) is the predominant physiological binder/inhibitor of SHMT. Finally, the model simulations indicate that the 5fTHF futile cycle dampens the stochastic noise in FOCM that results from both folate deficiency and a common ...
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Pharmacokinetic analysis of (6S)-5-formyltetrahydrofolate (1-CF), (6R)-5-formyltetrahydrofolate (d-CF) and 5-methyltetrahydrofolate (5-CH3-THF) in patients receiving constant iv infusion of high-dose (6R,S)-5-formyltetrahydrofolate (leuc... Straw JA, Newman EM (1988) Pharmacokinetic anal...
With n-butyllithium In tetrahydrofuran; hexane soln. of n-BuLi in hexane added dropwise to soln. of the acetal in THF at -78°C, stirred at -78°C for 5 h, dropwise addn. of trimethylborate, allowed to warm to 25°C with stirring overnight; aqueous workup, org. solvent removed und...
(0.40 mL) was added to a solution of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(dimethoxymethyl)-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine -1(2H)-carboxamide (obtained in step 13, 470 mg, 0.808 mmol) in THF (3 mL) and water (1 mL...
1-3 Solubility: soluble in aqueous n -butanol , aqueous ethanol, DMA, DME/ethanol, DMF, 1,4-dioxane, isopropanol , THF, and toluene. Analysis of Reagent Purity: by 1 H and 13 C NMR analysis, 2 , 3 by combustion analysis. 3 The corresponding diethyl acetal can be analyzed for purity...
methylene THF reductase-(NADPH)胺氧化还原酶类叶酸叶醛酸四氢叶酸盐类Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolic acid (5-CH(3)-H(4) folic acid), the methyl donor for the formation of methionine from homocysteine. A common C677T transition in the...
Monoclonal antibodyELISAMaize kernelsMaize is one of the most important staple food crops worldwide. 5-Formyltetrahydrofolate (5-F-THF), the most dominant and stable folate derivative in maize kernels, is important to human health and acts key roles in several metabolic pathways and biological ...
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