5-Aza-dC treatment induces mesenchymal-to- epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo. Biochem Biophys Res Commun. 2013;432(1):116-22.Ying Chen,Kai Wang,Richard Leach.5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell ...
- 《Chinese Journal of Cancer Prevention & Treatment》 被引量: 11发表: 2007年 Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer Aberrant DNA methylation patterns may be the earliest somatic genome changes in prostate cancer. Using real-time methylation-specific PCR, we...
(Method)Afterdifferenttreatmentsofdonorcellswith5-aza-dc,usedMTTtoselectthemostsuitabletreatmentconcentrationandtime,PIandHochest33342doublestaining,agarosegelelectrophoresisexperimentwereusedtodetectapoptosisofthecells,appliedkaryotypeanalysistomeasuretheeffectof5-aza-dconthechromosomes.(Result))Theresultsshowed,low...
Noobviousdifferenceintotalbodyweightgain,totaldietaryintakeamount,foodutilizationrateand systolicbloodpressurewasobservedbetween5’-nucleotidetreatmentgroupsandcontrolgroup.However,comparedwiththe ratsincontrolgroup,bodyweightsofmaleratsinnucleotidetreatmentgroupexhibitedasignificantincreaseinthefirst4weeks (P<0.05)....
Treatment of cells with 5-Aza-dC, an inhibitor of DNA methylation, resulted in decreased expression of GnT-V mRNA and β1,6-branched oligosaccharides along with reduced glycosylation of LAMP-1, a major substrate for GnT-V. This was accompanied by reduced chemotactic motility of the cells. ...
Covalent protein-DNA adducts can arrest replication and induce apoptosis, and these results raise the possibility that induction of PARP1-DNA adducts may contribute to cell killing in response to treatment with 5-aza-dC.doi:10.1016/j.dnarep.2020.102977Kostantin Kiianitsa a...
Effects of 20 μM 5-aza-dC Treatment on the 10q25 NeocentromereNicholas, C WongLee, H WongJulie, M QuachPaul, CanhamJeffrey, M CraigJenny, Z SongSusan, J ClarkK., H. Andy Choo
Effect of 5-aza-dC treatment on DNMT1 protein levels by Western blot analysis of pancreatic CAF and control fibroblast cultures.Jun, YuKimberly, WalterNoriyuki, OmuraSeungMo, HongAngela, YoungAng, LiAudrey, VincentMichael, Goggins
Conclusion The methyltransferase inhibitor 5-Aza-dC may become a potential therapeutic drug in the treatment of arthrofibrosis of the knee through inhibiting the proliferation of myofibroblasts.%目的:探讨甲基转移酶抑制剂5-氮杂-2'-脱氧胞苷(5-aza-2-deoxycyfidine,5-Aza-dC)对大鼠膝关节纤维化中肌...
Therefore, down-regulation of p16 and MGMT expression enhances the anti-proliferative effects of 5-Aza-dC and X-ray radiation. This discovery may provide novel ideas for the treatment of cervical cancer.doi:10.1002/cbf.3282Guan‐di Chen