Ying Chen,Kai Wang,Richard Leach.5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8/SVneo. Biochemical and Biophysical Research Communications . 2013ChenY, Wang K, Leach R. 5-Aza-dC treatment induces mesenchymal-to-epi- thelial transition ...
ratsincontrolgroup,bodyweightsofmaleratsinnucleotidetreatmentgroupexhibitedasignificantincreaseinthefirst4weeks (P<0.05).Similarly,totalfoodutilizationratesoftheratstreatedwith5’-nucleotideatdosesof0.01,0.04g/kgbwand 0.16g/kgbwexhibitedsignificantlyhigherthanthatofcontrolgroupinthefirst2weeks(P<0.05).Inaddition...
mentorTSAtreatment. CONCLUSION:Aberrantmethylationofp16 and hMLH-1 gene is a common event in the oc- currence and progression of gastric cancer. The methylation of promoter region in CPG island is a main cause for p16 and hMLH-1 gene tran- ...
p16基因在MGC-803细胞中无表达, 经TSA作用后无表达, 5-Aza-dC及联合作用后有较强表达(相对值为0.413, 0.546); 在MKN-45细胞中有很弱表达(相对值0.16), 经TSA, 5-Aza-dC及联合作用后有不同程度表达(相对值为0.174, 0.876, 0.858). hMLH-1基因在MGC-803中无表达, 经TSA作用后仍无表达, 5-Aza-dC及...
Results The sequential treatment with 5-Aza-2'-dC and TRAIL resulted in significant inhibition of the cell proliferation and apoptosis. Moreover,pretreatment of breast cancer cells with 5-Aza-2'-dC caused enhancement...
Conclusion The methyltransferase inhibitor 5-Aza-dC may become a potential therapeutic drug in the treatment of arthrofibrosis of the knee through inhibiting the proliferation of myofibroblasts.%目的:探讨甲基转移酶抑制剂5-氮杂-2'-脱氧胞苷(5-aza-2-deoxycyfidine,5-Aza-dC)对大鼠膝关节纤维化中肌...
Covalent protein-DNA adducts can arrest replication and induce apoptosis, and these results raise the possibility that induction of PARP1-DNA adducts may contribute to cell killing in response to treatment with 5-aza-dC.doi:10.1016/j.dnarep.2020.102977Kostantin Kiianitsa a...
Effects of 20 μM 5-aza-dC Treatment on the 10q25 NeocentromereNicholas, C WongLee, H WongJulie, M QuachPaul, CanhamJeffrey, M CraigJenny, Z SongSusan, J ClarkK., H. Andy Choo
Effect of 5-aza-dC treatment on DNMT1 protein levels by Western blot analysis of pancreatic CAF and control fibroblast cultures.Jun, YuKimberly, WalterNoriyuki, OmuraSeungMo, HongAngela, YoungAng, LiAudrey, VincentMichael, Goggins
Analysis of cell membrane markers showed a loss of the early differentiation antigens CD34 and CD33 from leukaemic bone marrow cells after 7 days of Aza-dC treatment, which is suggestive of leukaemic cell differentiation. In the small group of patients tested for DNA hypomethylation no association...