A series of novel 5-aminosalicylic acid derivatives of various nonsteroidal anti-inflammatory drugs (diclofenac, ibuprofen, indomethacin, naproxen, and salicylic acid) was synthesized, and the conjugates were assayed for anti-inflammatory activity and gastrointestinal toxicity. All the new derivatives ...
carboxylic acid esters (benzene compounds)ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The ...
Mechanism of action of 5-aminosalicylic acid and its derivatives. Clin Sci 1990; 78: 119-25 Greenfield SM, Punchard NA, Teare JP, et al. Review article: the mode of action of the aminosalicylates in inflammatory bowel disease. Aliment Pharmacol Ther 1993; 7: 369-83 Travis SPL, Jewell DP...
The goals of pharmacotherapy in Crohn disease are to reduce morbidity and prevent complications. Agent classes used include 5-aminosalicylic acid (5-ASA) derivatives, corticosteroids, immunosuppressive agents, biologic agents, and antibiotics. Next: 5-Aminosalicylic Acid Derivatives What to Read Next on...
5-Aminosalicylic Acid Derivatives Antibiotics, Other Corticosteroids Immunosuppressants TNF Inhibitors Alpha 4 Integrin Inhibitors Histamine H2 Antagonists Proton Pump Inhibitors Antidiarrheals Anticholinergic, Antispasmodic Agents Monoclonal Antibodies Corticosteroids, Rectal DMARDs, JAK Inhibitors Bile Acid Sequestra...
Garjani A., Davaran S., Rashidi M., Malek N.: Protective effects of some azo derivatives of 5-aminosalicylic acid and their pegylated prodrugs on acetic acid- induced rat colitis. DARU J. Pharm. Sci. 2004, 12, 24.Alireza G, Soodabeh D, Mohamadreza R, Nasrin M. Protective effects ...
4-Aminobenzaldehyde and sodium nitrite were dissolved in 50 mL of water in a molar ratio of 1:1.3. To this mixture, concentrated hydrochloric acid in a molar ratio of 1:4 was added. The reaction mixture was stirred at4∘Cin an ice bath for 30 min. Subsequently, a solution of sodium...
DERIVATIVES ARE PRESENTED 5-aminosalicylic acid acylated GROUP AMINO ACID glutamic acid or aspartic acid and / or have carboxide GROUP INVOLVED IN A LINK WITH PEPTIDE leucyl-prolyl RESIDUAL derivatives are useful as prodrugs of 5- aminosalicylic.PELLICCIARI, ROBERTO VIA CASSANESE...
Hence, in this work, four 5-aminosalicylic acid derivatives ( C1 - C4 ) were synthesized and evaluated. The results showed that C1 has anti-inflammatory activity (ear model) comparable to indomethacin, while C2 , C3 and C4 showed better MPO inhibitory effects when evaluated in vitro using ...
5-AMINOSALICYLIC ACID DERIVATIVES OF NON-STEROIDAL ANTIINFLAMMATORY ACIDSof EP0195582 The present invention relates to amide derivatives of formula (1):- and pharmaceutically acceptable salts and esters thereof where R is a single bond or a substituted or unsubstituted alkanediyl group, R is a ...