1984. 5-Aminoimidazole ribotide as the precursor of all the carbon atoms of the pyrimidine moiety. J Am Chem Soc 106: 3857-3860.Estramareix, B., and M. Therisod. 1984. Biosynthesis of thia- mine: 5-aminoimidazole ribotide as the precursor of all the carbon atoms of the pyrimidine ...
4) 5-amino-imidazole ribotide 5-氨基咪唑核苷酸5) 5-amino-4-imidazolecarboxamide-riboside 5-氨基-4-甲酰胺核苷酸6) [(4 methylimidazol 1 yl)methylene] β alanine 4-甲基咪唑基-5-亚甲基-β-丙氨酸补充资料:咪唑安定,咪唑二氮卓,马来酸咪达唑仑 药物名称:咪唑安定英文名:Midazolam别名:咪达唑仑,...
carboxyaminoimidazole ribotide 中文别名: CBNumber: CB71370411 分子式: C9H14N3O9P 分子量: 339.2 MOL File: 6001-14-5.mol 化学性质安全信息用途供应商11 carboxyaminoimidazole ribotide化学性质 沸点: 865.9±75.0 °C(Predicted) 密度: 2.30±0.1 g/cm3(Predicted) ...
After injection of AICA riboside (200 mg/kg, iv) in nude mice bearing MCF-7 xenografts, MTX (50 mg/kg, iv) significantly increased the concentrations of AICA riboside and its active metabolite AICA ribotide in tumors. Conclusion: MTX and AICA riboside exert synergistic anticancer action against...
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.| Baggott, JE., et al. 1986. Biochem J. 236: 193-200. PMID: 24316...
Proliferation of cells was also determined by [3H]thymidine ribotide ([3H]TdR) incorporation into DNA. Each cell line was plated at a density of 0.25 × 106 cells/well, and cells were incubated for 18–24 h with or without AICAR at various concentrations and then exposed to 37 kBq/ml [...
中文名称: carboxyaminoimidazole ribotide 中文同义词: 英文名称: carboxyaminoimidazole ribotide 英文同义词: carboxyaminoimidazole ribotide;1-(5-O-Phosphono-β-D-ribofuranosyl)-5-amino-1H-imidazole-4-carboxylic acid;5-Aminoimidazole-4-carboxylic acid ribonucleotide;5'-Phosphoribosyl-5-aminoimidazole-4-carbox...
It is known that methotrexate treatment blocks de novo purine biosynthesis, resulting in the accumulation of the intermediate 5-aminoimidazole-4-carboxamide ribotide and its metabolites. It is hypothesized that these substances are involved in the mechanism of action of low dose methotrexate therapy by...
Szabados, E., Hindmarsh, E.J., Phillips, L., Duggleby, R.G., and Christopherson, R.L, 1994, 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells:purification, pH dependence, and inhibitors. Biochemistry , 33: 14237. View Article...
Germany A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for simultaneous determination of 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICA riboside) and its active metabolite 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranotide (AICA ribotide) in mice ...