With analogs in which the oxygen atom of the 1-(benzyloxy) moiety was deleted (15, 16), the phenyl group replaced by aliphatic rings (17, 18), or the “tetrazole-truncated” compounds (19a-b), no activity was observed. The N-(5-phenyltetrazol-1-yl)-benzamide 20 was inactive. ...
Tetrahedron Lett. 1993, 34, 1757-1760.Boteju, L. W., Hruby, V. J. (1993) Tryptophan-containing 1,5-tetrazole dipeptide analogs: synthesis of Trp Ψ[CN4]Nle as a cis amide bond surrogate. Tetrahedron Lett. 34: pp. 1757-1760
Nanocrystalline ZnO as an Efficient Heterogeneous Catalyst for the Synthesis of 5‐Substituted 1H‐Tetrazoles Nanocrystalline ZnO is an effective heterogeneous catalyst for the [2+3]-cycloaddition of sodium azide with nitriles to afford 5-substituted 1H-tetrazoles ......
5-[4-(Benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogs: new reversible, highly potent, and selective monoamine oxidase type B in... Thirty-three new 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives including related analogues, designed as inhibitor...
S. Bhadoriya, "QSAR anal- yses and pharmacophore studies of tetrazole and sulfonamide analogs of imidazo[4, 5-b]pyridine using simulated annealing based feature selection," Journal of Saudi Chemical Society. In press. [69] R. D. Cramer, D. E. Patterson, and J. D. Bunce, "Comparative ...
Two salts and one cocrystal based on H2BT (1H, 1′H-5,5′-bitetrazole), DATr (4,5-diamino-4H-1,2,4-triazole), 1MAT (1-methyl-5-aminotetrazole) and 2MAT (2-methyl-5-aminotetrazole) were synthesized, which corresponding to the different pKa values of three isomeric coformers. ...
One-Pot Synthesis of 2,5-Diaryl 1,3,4-Oxadiazoles via Di-tert-butyl Peroxide Promoted N-Acylation of Aryl Tetrazoles with Aldehydes A metal- and base-free protocol for one-pot synthesis of 2,5-diaryl 1,3,4-oxadiazoles via a radical-promoted cross-dehydrogenative coupling strategy was d...
In the chain-extension step, 0.1 ml of the amidophosphite is reacted with 0.37 ml of the tetrazole solution (0.5 M) with the support-bound 5′-hydroxyl groups of the oligonucleotide. A coupling time of 12 minutes is followed by standard capping, oxidation and, to prepare for the next ...
Suitably, when R2, is an optionally substituted aryl or heteroaryl ring, the ring is an optionally substituted phenyl, imidazole or tetrazole ring. Another aspect of the present invention is the novel compounds of Formula (IV) and (IVa). Suitably, for compounds of Formula (IV) and (IVa)...
In addition, when a compound contains both a basic moiety, such as an amine, pyridine or imidazole, and an acidic moiety such as a carboxylic acid or tetrazole, zwitterions may be formed and are included within the term “salt” as used herein. Salts derived from pharmaceutically acceptable ...