5-HT4 Rezeptoragonisten 5-HT4 receptor agonistsHaruhiko KikuchiHiroaki SatohMasashi SuzukiRuta FukutomiMasahiro UenoKoichiro HagiharaTakeo AraiSetsuko MinoYumiko Noguchi
5-HT 再摄取的抑制作用 在大脑中，信息通过化学突触从一个神经细胞传递到另一个神经细胞。 发送信息...
Define 5-HT. 5-HT synonyms, 5-HT pronunciation, 5-HT translation, English dictionary definition of 5-HT. n. An organic compound, C10H12N2O, that is formed from tryptophan and is found especially in the gastrointestinal tract, the platelets, and the nervo
(5-HT)是一 种泛素单胺,是神经细胞突触的神经递质之一.5- HT 受体在偏头痛中发挥不可替代的作用.5-HT 受 体亚型逐渐被定义,目前发现属于 G 蛋白偶联受体 的有 5-HT1/2/4/5/6/7 受体.属于半胱氨酸环配体离 子通道的是 5-HT3 受体,是一种配体门控 Na+/K+通 道,调控细胞质膜去极化.激活 5-HT1...
A 5-HT4 receptor transmembrane network im- plicated in the activity of inverse agonists but not agonists. J Biol Chem 277: 25502-25511, 2002.Joubert L, Claeysen S, Sebben M, Bessis AS, Clark RD, et al. A 5-HT4 receptor transmembrane network implicated in the activity of inverse ...
Selective serotonin reuptake inhibitors (SSRIs) display a delayed onset of action of several weeks. Past work in naive rats showed that 5-HT4 receptor agonists had rapid effects on depression-related behaviors and on hippocampal neurogenesis. We decided
being CV-1 (simian) in origin, and carrying the SV40 genetic material (COS)-7 cells, with that of the 5-HT4(b) and 5-HT4(a) splice variant, it showed a smaller fraction of receptors coupled to G-proteins and the 5-HT4 receptor antagonist GR113808 behaved as a partial agonist[28...
Interestingly, we demonstrated that 5-HT(4) receptors physically interacted with the mature form of ADAM10. Stimulation of 5-HT(4) receptors by an agonist further increased sAPPα secretion, and this effect was mediated by cAMP/Epac signaling. These findings describe a new mechanism whereby a ...
Name4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide SynonymMore Synonyms Cinitapride Biological Activity DescriptionCinitapride is an orally active 5-HT4 agonist and D2 antagonist. Cinitapride shows gastroprotective properties on mucosal injury. Cinitapride can...
Advancements in precision medicine drive the 5-HT2 agonist market by enabling selective targeting of specific receptor subtypes (e.g., 5-HT2A or 5-HT2C),...