5-HT1A受体 1. In the present study, extracellular recording was used to examine the neuronal activity of the basolateral nucleus (BL) of the amygdala and the effects of systemic administration of the selective 5-HT1A receptor antagonist WAY-100635 on the neuronal activity in the normal rats and...
5-HT1A 受体活化可能在血清素释放剂(SRAs)如摇头丸MDMA(“Ecstasy”)的作用中起重要作用。 已经证明5-HT1A 受体的激活通过抑制脑的各个区域中的谷氨酸和乙酰胆碱的释放而削弱记忆和学习。已知5-HT1A 激活可改善前额皮质相关的认知功能。相反,5-HT1A 体拮抗剂例如lecozotan显示促进啮齿动物中的某些类型的学习和记忆,...
目的 观察急性心肌缺血时大鼠丘脑束旁核(parafascicular nucleus,Pf)μ1-阿片受体(μ1-opioid receptor,MOR1)mRNA和5-羟色胺1A受体(5-hydroxytryptamine receptor 1A,5-HT1A receptor)mRNA不同时点表达的变化以及吗啡(Morphine)和曲马多(Tramadol,TMD)预先痛觉干预对其表达的影响,探讨MOR1和5-HT1A受体在丘脑束旁核痛...
3 讨论 药物直接作用或药物相互作用使外周和中枢 神经系统 5‑HT 递质蓄积和/或 5‑HT 受体(主要是 5‑HT1A 和 5‑HT2A 亚型)过度激活,致神经传递效应 增加,均有可能导致 SS[5‑6].SS 的诊断一般通过症 状,体征和 5‑HT 能药物用药史确定 ,目[5‑7,56] 前尚 无 SS 诊断的金标准,应用...
In order to investigate the mechanisms of 5-HT1A receptor subtype in the sensory modulation,double immunofluoresence histochemistry was used to observe the coexistence of 5-HT1A receptor subtype with substance P(SP),vesicular glutamate transporter I(VGLUT1)and galanin(Gal)in the rat dorsal root ...
Objective The purpose of this study was to investigate the changes in expression of 5-HT1A receptor mRNA in rat parafascicular nucleus(Pf)induced by coronary artery occlusion(CAO). 目的观察急性心肌缺血期大鼠丘脑束旁核神经元5-HT1A受体mRNA不同时间点表达的变化,以探讨5-HT1A受体在丘脑束旁核痛觉整...
3 讨论 药物直接作用或药物相互作用使外周和中枢 神经系统 5‑HT 递质蓄积和/或 5‑HT 受体(主要是 5‑HT1A 和 5‑HT2A 亚型)过度激活,致神经传递效应 增加,均有可能导致 SS[5‑6].SS 的诊断一般通过症 状,体征和 5‑HT 能药物用药史确定 ,目[5‑7,56] 前尚 无 SS 诊断的金标准,应用...
It has been demonstrated that selective 5-HT1Aantagonist,α2 antagonist and 5-HT2Aantagonist can accelerate the response of classic antidepressants. 研究表明,选择性5-HT1A、α2自身受体拮抗剂及5-HT2A受体拮抗剂可加快5-羟色胺重摄取抑制剂及去甲肾上腺素重摄取抑制剂等抗抑郁药物的起效速度。补充...