5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant ...
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limit...
5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limit...
体内:5-Fluorouracil (23 mg/kg,每周 3 次) 持续 14 天,在处理开始后第 3 天诱导与急性肠道炎症相关的胃肠道传输加速,这可能导致第 7 天后观察到的 ENS 持续变化和 14 项处理导致胃肠道传输延迟和结肠运动障碍[4]。 MCE尚未独立证实这些方法的准确性。仅供参考。 动物实验:每周 3 次,小鼠通过 26 号针头...
胃癌和结直肠癌是常见的消化道恶性肿瘤,胃癌发病率和死亡率分列癌症第5和第4位,而结直肠癌则分别高居第3和第2位1,2。目前,胃癌和结直肠癌的治疗主要有外科手术、放疗以及包括化疗、靶向治疗和免疫治疗在内的全身治疗。新药和新技术的涌现,极大改善了化疗的临床应用,为临床医生提供了新的治疗手段。本文介绍了1例...
5-Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the knowledge of its mechanism of action, various treatment modalities have been developed over the past few decades to increase its anti-cancer activity. But drug resistance has greatly affected the clin...
生物活性 5-Fluorouracil 是一种有效的抗肿瘤剂,通过抑制胸苷酸合成酶从而消耗细胞内dTTP来影响嘧啶合成。[1-4] In Vitro 5-氟尿嘧啶 (5-Fu) 和多柔比星 (Dox) 显示出协同抗癌功效。 5-Fu / Dox-DNM对人乳腺癌 (MDA-MB-231) 细胞的IC50值为0.25μg/ mL, 与Dox-DNM和5-Fu相比, 细胞毒性增加11.2倍...
胃癌和结直肠癌是常见的消化道恶性肿瘤,胃癌发病率和死亡率分列癌症第5和第4位,而结直肠癌则分别高居第3和第2位1,2。目前,胃癌和结直肠癌的治疗主要有外科手术、放疗以及包括化疗、靶向治疗和免疫治疗在内的全身治疗。新药和新技...
英文名称5-Fluorouracil CAS51-21-8 分子式C4H3FN2O2 分子量130.08 储存条件2-8℃ 纯度98.0-102.0% 外观(性状)白色粉末 单位瓶 5-氟脲嘧啶简称氟脲嘧啶,为嘧啶类抗代谢药属于抗肿瘤药,本品仅用于生化研究。 5-氟尿嘧啶原理: 5-氟尿嘧啶类抗肿瘤药物是一类广谱抗肿瘤药物,通过多种途径、多种代谢产物来干扰肿瘤...
Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。 溶解性:DMSO : 13 mg/mL (100 mM) Ethanol : 1.3 mg/mL (10 mM) 体外研究: Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly ente...