5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant ...
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limit...
Colorectal cancer is one of the most frequently diagnosed cancers worldwide. Gut flora can modulate the host response to chemotherapeutic drugs. However, the understanding regarding the relationship between the gut microbiota and the antitumor efficacy of 5- Fluorouracil (5-FU) treatment is limited. ...
Our research demonstrates that SOD2 can serve as an inhibitor of ferroptosis by activating AKT, and stabilizing GPX4 protein, which subsequently induces 5-fluorouracil resistance. These findings reveal a mechanism whereby H. pylori can promote gastric carcinogenesis by activating the NF-κB/SOD2/AKT/...
NCI Dictionary of Cancer Terms5-fluorouracil;5-FU;Efudex;Fluoroplex;fluorouracil NCI Drug DictionaryEfudex NIST Chemistry Reference2,4-Pyrimidinedione, 5-fluoro-(51-21-8) IARC3 (Vol. 26, Sup 7) 1987 ATC codeL01BC02,L01BC52 Proposition 65 ListFluorouracil ...
英文名称5-Fluorouracil CAS51-21-8 分子式C4H3FN2O2 分子量130.08 储存条件2-8℃ 纯度98.0-102.0% 外观(性状)白色粉末 单位瓶 5-氟脲嘧啶简称氟脲嘧啶,为嘧啶类抗代谢药属于抗肿瘤药,本品仅用于生化研究。 5-氟尿嘧啶原理: 5-氟尿嘧啶类抗肿瘤药物是一类广谱抗肿瘤药物,通过多种途径、多种代谢产物来干扰肿瘤...
Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。 溶解性:DMSO : 13 mg/mL (100 mM) Ethanol : 1.3 mg/mL (10 mM) 体外研究: Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly ente...
Nat Rev Cancer, 2003, 3(5), 330-338.[2] Peters et al (2002) Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Biochim.Biophys.Acta. 1587 194. [3] Ghoshal and Jacob (1997) An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug....
Methods: Surgically resected colorectal cancer specimens from 89 patients were decellularized to produce patient- derived scaffold, which were seeded with HT29 cells, cultured for 3 weeks, and treated with 5-fluorouracil. Gene expression changes of adapted and treated HT29 cells were monitored ...
Event-free survival (EFS) in MATTERHORN: A randomized, phase 3 study of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin and docetaxel chemotherapy (FLOT) in resectable gastric/gastroesophageal junction cancer (GC/GEJC). 标题:MATTERHORN研究无事件生存(EFS)期分析:Ⅲ期随机试验评估度伐利尤单抗(Du...