英文名称: 5,10-Methenyltetrahydrofolate Synthetase Human Recombinant 总访问: 219 国产/进口: 进口 半年访问: 21 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: ENZ-096 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
5,10-亚甲基四氢叶酸(5,10-CH=THF)是还原的叶酸,可用于抗贫血和肿 瘤药物的解毒拮抗剂等。【背景技术】[0002] 5, 10-亚甲基四氢叶酸,(5, l〇-Methenyltetrahydrofolate,简称为 5,1〇-〇1=1'册),化学名称4-[4-(3-氨基-1-氧代-1,4,5,6,6&,7-六氢-8-咪唑[1,5,幻 并碟啶-10-正离子-...
蛋白别名: 5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; FLJ30410; methenyl-THF synthetase; MTHFS 基因别名: HsT19268; MTHFS UniProt ID: (Human) P49914 Entrez Gene ID: (Human) 10588 功能 ATP binding folic acid binding 5-formyltetrahydrofolate cyclo-liga...
5,10-CH2-THF is synthesized from tetrahydrofolate (THF) through a series of enzymatic reactions. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the transfer of a methylene group from 5,10-methenyltetrahydrofolate (5,10-CH=THF) to THF, forming 5,10-CH2-THF. Metabolic Functions...
AdoMet S-adenosylmethionine BAC bacterial artificial chromosome NoCTP no chloroplast targeting sequence 5,10-MTHF 5,10-methenyltetrahydrofolate THF tetrahydrofolate RACE rapid amplification of cDNA ends IPTG isopropyl 1-thio-β-d-galactopyranoside nt nucleotide. ...
methenyltetrahydrofolate; CH2THF, 5,10-methylenetetrahydrofolate; CH3DNA, methylated DNA; CH3THF, 5-methyltetrahydrofolate; DHF, dihydrofolate; dTMP, deoxythymidine 5′-monophosphate; dUMP, deoxyuridine 5′-monophosphate; FAD, flavine adenine dinucleotide; Hcy, homocysteine; Met, me...
5-formyltetrahydrofolate (5-formylTHF) is administered in these treatments, either as a rescue agent or as an enhancer. The only enzyme known to use 5-formylTHF as a substrate is 5,10-methenyltetrahydrofolate synthetase (MTHFS). This enzyme catalyzes the conversion of 5-formylTHF to 5,1...
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1...
[2]Investigations of the Roles of Arginine 115 and Lysine 120 in the Active Site of 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae[J].Amber N.Hancock,R.Shane Coleman,Richard T.Johnson,Catherine A.Sarisky,Timothy W.Johann.The Protein Journal.2008(5) ...
FU inhibits the synthesis of dTMP through the formation of FdUMP, which binds TS. DHF: dihydrofolate, DHFR: dihydrofolate reductase, SHMT1: serine hydroxymethyltransferase 1, MTHFR: methylenetetrahydrofolate reductase, MTHFD: methylenetetrahydrofolate dehydrogenase, MTHFS: methenyltetrahydrofolate ...