英文名称: 5,10-Methenyltetrahydrofolate Synthetase Human Recombinant 总访问: 227 国产/进口: 进口 半年访问: 4 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: ENZ-096 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
5,10-亚甲基四氢叶酸(5,10-CH=THF)是还原的叶酸,可用于抗贫血和肿 瘤药物的解毒拮抗剂等。【背景技术】[0002] 5, 10-亚甲基四氢叶酸,(5, l〇-Methenyltetrahydrofolate,简称为 5,1〇-〇1=1'册),化学名称4-[4-(3-氨基-1-氧代-1,4,5,6,6&,7-六氢-8-咪唑[1,5,幻 并碟啶-10-正离子-...
5,10-亚甲基四氢叶酸,(5,10-Methenyltetrahydrofolate,简称为5,10-CH=THF),化学名称:N-[4-(3-氨基-1-氧代-1,4,5,6,6a,7-六氢-8-咪唑[1,5,f]并碟啶-10-正离子-8-基)苯甲酰]-L-谷氨酸,结构式如下: 它是还原的叶酸,直接或间接转化为5,10-亚甲基四氢叶酸的聚谷氨酸盐后,作为胸甘氨酸合成酶...
Methenyltetrahydrofolate synthetase (MTHFS) catalyses the obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates. We have isolated and sequenced a human MTHFS cDNA which is 872-bp long and codes for a 203-amino-acid protein of 23229 ...
蛋白别名:5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; FLJ30410; methenyl-THF synthetase; MTHFS 基因别名:HsT19268; MTHFS UniProt ID:(Human) P49914 Entrez Gene ID:(Human) 10588 功能 ATP bindingfolic acid binding5-formyltetrahydrofolate cyclo-ligase activitymetal ...
Mycoplasma pneumoniae 5,10-methenyltetrahydrofolate synthetase [MTHFS; also known as 5-formyltetrahydrofolate cycloligase; Enzyme Commission (EC) 6.3.3.2] belongs to a large cycloligase protein family with 97 sequence homologues from bacteria to human. To help define the molecular (biochemical and ...
5,10-CH2-THF is synthesized from tetrahydrofolate (THF) through a series of enzymatic reactions. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the transfer of a methylene group from 5,10-methenyltetrahydrofolate (5,10-CH=THF) to THF, forming 5,10-CH2-THF. Metabolic Functions...
In tetrahydrofolate (THF) metabolism, single carbon units in the oxidation states of formyl-, methenyl- and methylene-THF are interconverted by a series of three enzymes: 5,10-methylene-THF dehydrogenase (deh), 5,10-methenyl-THF cyclohydrolase (cyc) and 10-formyl THF synthetase (syn) [4]...
methenyltetrahydrofolate; CH2THF, 5,10-methylenetetrahydrofolate; CH3DNA, methylated DNA; CH3THF, 5-methyltetrahydrofolate; DHF, dihydrofolate; dTMP, deoxythymidine 5′-monophosphate; dUMP, deoxyuridine 5′-monophosphate; FAD, flavine adenine dinucleotide; Hcy, homocysteine; Met, me...
5-formyltetrahydrofolate (5-formylTHF) is administered in these treatments, either as a rescue agent or as an enhancer. The only enzyme known to use 5-formylTHF as a substrate is 5,10-methenyltetrahydrofolate synthetase (MTHFS). This enzyme catalyzes the conversion of 5-formylTHF to 5,1...