Perinatal exposure to low-dose 2,2′,4,4′-tetrabromodiphenyl ether affects growth in rat offspring: What is the role of IGF-1? 2009. Perinatal exposure to low-dose 2,2',4,4'- tetrabromodiphenyl ether affects growth in rat offspring: What is the role of IGF-1? Toxicology ... A ...