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4-Hydroxytamoxifen是tamoxifen的活性代谢产物,是一种选择性的雌激素受体调节分子,在乳腺癌的治疗和化学疗法中应用广泛化疗药物它莫西芬的代谢产物,抑制许多潜在雌激素的活性,也能激活如膜间脂质过氧化反应的抑制剂。 4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor mo...
Update on percutaneous 4-OH tamoxifen4-hydroxy tamoxifène, Marqueurs de prolifération, CCIS, 4-hydroxy-tamoxifen, Proliferative markers, DCISPhilippe Rouanet
As tamoxifen sensitivity depends on the estrogen receptor (ERα) expression level, we evaluated the effect of PUGNAc+glucosamine on the expression of this receptor. We observed that O-GlcNAcylation-inducing treatment significantly reduced the expression of ERα mRNA and protein, suggesting a potential...
"G4 PAMAM-Tf and tamoxifen 他莫昔芬修饰聚酰胺-胺树枝状聚合物" G4 PAMAM@α-d-galactose 半乳糖修饰树枝状聚合物 dendrimers (G2.5 and G3.5 COOH) PAMAM dendrimers G6-amine 氨基化树枝状聚酰胺胺第6代 Thio G0.5-aldehyde DBCO功能化的PAMAM ...
Approximately 80% of breast cancer (BC) cases are estrogen receptor positive (ER+) and sensitive to hormone treatment; Tamoxifen is a prodrug, and its main plasmatic active metabolites are 4-hydroxytamoxifen (4-OH Tam) and endoxifen. Despite the effectiveness of tamoxifen therapy, resistance can...
Johnson, M.D.; Westley, B.R.; May, F.E. 1989: Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells British Journal of Cancer 59(5): 727-738PreviousNext Preview Quick Search Search Search Search Full Text Article...
Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines The intensive use of chemotherapeutic agents for the treatment of cancer has resulted in the cure or improved survival of many patients. But unfortunately, many ...
Microsphere-encapsulated 4OH-Tamoxifen: a new sustained release delivery system with antitumour activity against DMBA-induced mammary carcinoma in sprague-dawley ratsConclusions✓ A significant antitumor activity was displayed by TAM and MS/4OH-TAM✓ A single SC injection of MS/4OH-TAM displayed ...
DIFFERENCE IN BIOLOGICAL CHARACTER OF ENDOXIFEN, 4-OH TAMOXIFEN, TOREMIFENE AND FULVESTRANT FOR MCF-7 CELLPaclitaxel (TXL) and docetaxel (TXT), especially TXL, cause neurotoxicity manifested as polyneuropathy. In clinical practice, detailed knowledge of the symptoms and effect on quality of life (...