( 18QB1403400 );上海市自然科学基金探索类项目( 17ZR1441600 )作者简介:王跨陡( 1970 —),男,副主任法医师,主要从事毒品、毒物分析检测研究; E-mail : wangkd001@163.com合成大麻素类新精神活性物质 4F-MDMB-BUTINACA 和MDMB-4en-PINACA 的检测王跨陡1 ,袁晓亮 2 ,张玉荣 1 ,胡钧健 2 ,曹芳琦 2...
5F-MDMB-PINACA and 4F-MDMB-BINACA are synthetic cannabinoids (SCs) that elicit cannabinoid psychoactive effects. Defining pharmacokinetic鈥損harmacodynamic (PK鈥揚D) relationships governing SCs and their metabolites are paramount to investigating their in vivo toxicological outcomes. However, the ...
We demonstrated that similar enzymatic isoforms were implicated in the metabolism of 5F-MDMB-PINACA and 4F-MDMB-BINACA. Our in vivo t1/2 determinations verified the rapid elimination of parent SCs and suggest prolonged circulation of their EHMs. The pronounced attenuation of the potencies and ...
“合成大麻素类新精神活性物质4F-MDMB-BUTINACA和MDMB-4en-PINACA的检测”出自《法医学杂志》期刊2021年第4期文献,主题关键词涉及有法医学、毒物分析、新精神活性物质、傅里叶变换红外光谱、气相色谱-质谱法、高分辨质谱法、核磁共振波谱法、合成大麻素等。钛学术提供该文
This is the first detailed reporting of MDMB-4-en-PINACA and 4F-ABUTINACA associated fatality, which can help the routine forensic work. The scientific literature on the symptoms associated with these substances are evaluated, along with the pharmacological properties and possible mechanism of death...
Figure 1. Chemical structure of MDMB-4en-PINACA (left) and 4F-ABUTINACA (right). 4F-ABUTINACA—also known as N-(4-fluorobutyl)-APINACA or 4F-ABINACA, with the IUPAC name N-(1-adamantyl)-1-(4-fluorobutyl)indazole-3-carboxamide—is a fourth generation indazole-adamantyl-derived SCR...