苯丁酸钠Sodium 4-phenylbutyrate 苯丁酸钠Sodium 4-phenylbutyrate (4-PBA sodium) 是一种组蛋白去乙酰化酶 (HDAC) 和内质网应激 (ERS) 抑制剂,可用于癌症和感染等疾病的研究。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体外研究 苯丁酸钠Sodium 4-phenylbutyrate (...
PBA treatment strongly reduced the severe hyperglycemia observed in obese AhIAPP mice in fasting and fed conditions throughout the study. This effect was paralleled by a decrease in hyperinsulinemia. Importantly, PBA treatment reduced the prevalence and the severity of islet amyloid deposition in AhI...
巴弗洛霉素A1的加入导致LC3II的积累,而苯丁酸(4-PBA)基本上减少了这种积累。 LPS降低p62的水平,而苯丁酸在LPS刺激48小时后逆转这种降低。具有LPS诱导的AVO的细胞的百分比在48小时时增加,而苯丁酸显著降低该百分比。具体而言,在苯丁酸处理后,具有AVO的细胞的百分比从61.6%降低至53.1%,支持苯丁酸抑制LPS诱导的自噬。
1) 4-phenylbutyrate(4PBA) 4-丁酸苯酯2) 4-Chlorobutyl benzoate 苯甲酸-4-氯丁酯3) ethyl 4-oxo-4-phenylbutanoate 4-氧代-4-苯基-丁酸乙酯 1. The reaction of ethyl diazoacetate(EDA) with N-(styryl)morpholine catalyzed by copper salts provided ethyl 4-oxo-4-phenylbutanoate: in good yield...
生化机理苯丁酸钠是 4-苯基丁酸(4-PBA)或 4-苯基丁酸的一种盐。苯丁酸钠是一种组蛋白去乙酰化酶抑制剂,用于治疗尿素循环障碍。 储存温度-80℃储存 运输条件超低温冰袋运输 产品介绍 Information Sodium Phenylbutyrate Sodium phenylbutyrate is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium...
The use of 4PBA in the manufacture of a medicament useful to treat cognitive disorders in dementias coursing with tauopathies is described. The treatment with 4PBA improves cognitive deficit in a classic murine experimental model of Alzheimer's Disease (AD) (Tg 2576) that is accompanied by ...
4-PBA (Sodium Phenylbutyrate) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
4-phenylbutyrate (PBA) is a small molecule that restores cognitive deficits in animal models of Alzheimer's disease (AD). Although the molecular basis of the cognitive benefits of PBA remains unknown, a multi-modal/multi-target mechanism has been proposed. Putative targets of this drug are diffe...
英文别名:Sodium 4-phenylbutanoate;SPB;SODIUM PHENYLBUTYRATE;PBNA;PHENYL N-BUTYRATE SODIUM SALT;4-PHENYLBUTYRATE, NA;4-PHENYLBUTYRIC ACID SODIUM;4-PHENYLBUTYRIC ACID SODIUM SALT;4PBA;4PBA SODIUM;Tributyrate;4-PHENYLBUTYRATE;Sodium 4-phenylbutyrate;Sodium Phenylbutyrat;4-PBA,4-Phenylbutyric acid,4-phen...
4-PBA 4-phenylbutyric acid PERK PKR-like endoplasmic reticulum kinase SREBP sterol-regulatory element binding protein UPR unfolded protein response XBP1 X-box binding protein 1 [S] The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of si...