4-Hydroxycoumarin is biosynthesized from malonyl-CoA and 2-hydroxybenzoyl-CoA by the enzyme 4-hydroxycoumarin synthase. It is a pharmaceutical intermediate used in the production of anticoagulants, it is also the antagonist of vitamine K. anticoagulant; it can also...
Remarkably, function-based enzyme bioprospecting leads to the identification of a characteristic FabH-like quinolone synthase from Pseudomonas aeruginosa with high efficiency on the 4HC-forming reaction, which promotes the high-level de novo biosynthesis of 4HC in Escherichia coli (~500mgl in shake ...
BIS is a sub- class of chalcone synthase (CHS)-like type III polyketide syn- thases (PKSs). However, no other type III PKS with sequence similarity has been identified to catalyse the 4HC-forming reac- tion. By structure-based examination of bacterial secondary metabolites, we identified ...
Glucosamine-6-phosphate synthase4-HydroxycoumarinL-Proline2-MercaptobenzimidazoleIn this paper, we described the synthesis of 3(1H‐benzimidazollsulfanyl)(aryl) methyl]ydroxyヽhromenne derivatives by one﹑ot threeヽomponent reaction between 4﹉ydroxycoumarin, substituted aldehydes and 2﹎ercapto...