An example is 4-hydroxybutyryl-CoA dehydratase (4-BUDH) from Clostridium aminobutyricum that interconverts 4-hydroxybutyryl-CoA to crotonyl-CoA. 4-BUDH is functional as a homotetramer with two active sites per dimer and displays a distinctive active site architecture with the [4Fe–4S] 2+ ...
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4-Hydroxybutyryl-CoA dehydratase catalyzes the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA, which involves cleavage of an unactivated beta-C-H bond. The enzyme also catalyzes the apparently irreversible isomerization of vinylacetyl-CoA to crotonyl-CoA. Addition of crotonyl-CoA to the...
(R)- and (S)-gamma-[3-(2)H(1)]butyrolactones have been synthesised from (R)- and (S)-glycidol, respectively, and used to demonstrate that it is the pro-(S) hydrogen atom that is stereospecifically abstracted from C-3 of 4-hydroxybutyryl-CoA by 4-hydroxybutyryl-CoA dehydratase, and...
4-Hydroxybutyryl-CoA dehydratase from Clostrid- ium aminobutyricum: Characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction. Biochemistry 1996;35:11710-8.Muh U, Cinkaya I, Albracht SP, Buckel W (1996) 4-Hydroxy- butyryl-CoA dehydratase from Clostridium ...
Assay of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum. FEMS Microbiol Lett. 1990 Jul; 58 (2):187–191.Willadsen P, Buckel W (1990) Assay of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum. FEMS Micro- biol Lett 58:187-191...
4-Hydroxybutyryl-CoA dehydratase from cluster and one flavin adenine dinucleotide (FAD) molecule per homotetramer. Incubation of the enzyme with its substrate under equilibrium conditions followed by freezing at 77 K induced the EPR-spectrum of a neutral flavin semiquinone ( = 2.005, linewidth...
1997. Mossbauer study of 4-hydroxybutyryl- CoA dehydratase--probing the role of an iron-sulfur cluster in an overall non-redox reaction. Eur J Biochem 248:380 -384. http://dx.doi.org/10 .1111/j.1432-1033.1997.t01-1-00380.x.Mu¨ h, U., Buckel, W., and Bill, E. (1997). Mo...
Ulrike NäserNaser U (2004) Study of the reaction mechanism of 4-hydroxybutyryl-CoA dehydratase using isotopically labelled substrates and model compounds. PhD-Thesis, Newcastle University Newcastle upon Tyne, UK.
Phylogenetic tree of 4-hydroxybutyryl-CoA dehydratase proteins.Zhiping WangFeng GuoLili LiuTong Zhang