Antimalarials: Synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites - De, Byers, et al. - 1997De, D.; Byers, L. D.; Krogstad, D. J. Antimalarials: synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites. J. Heterocycl. Chem. 1997...
Chloroquine (CQ) and its hydroxy-analogue hydroxychloroquine (HCQ), both 4-aminoquinolines, have been extensively used in the treatment of malaria in the last century, but the continuous emergence of drug-resistant strains of Plasmodium falciparum has accelerated the development of new antimalarial dr...
The quantitative structure-activity relationship (QSAR) analyses were carried out for a series of new side chain modified 4-amino-7-chloroquinolines to find out the structural requirements of their antimalarial activities against both chloroquine sensitive (HB3) and resistant (Dd2) Plasmodium falciparum...
Antimalarials: Synthesis of 4-aminoquinolines that circumvent drug resistance in malaria parasites - De, Byers, et al. - 1997 () Citation Context ...n (53%). Synthesis of compound 10 was achieved from 4,7-dichloroquinoline and the appropriate 1,n-alkyldiamine. The two starting materials ...
Antimalarial activity of novel 4-aminoquinolines active against drug resistant strainsSrinivasarao Kondaparla
S. Kondaparla, A. Soni, A. Manhas, K. Srivastava, S.K. Puri, S.B. Katti, Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains, RSC Adv. 6 (2017) 105676-105689.S. Kondaparla, A. Soni, A. Manhas, K. Srivastava, S.K. Puri, S.B....
Chloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index). However, CQ is no longer used alone to treat patients with Plasmodium falciparum due to the emergence and spread of CQ-resistant strains, also reported for P. vivax. Despite CQ...
Amoidaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage. The observed drug toxicity is believed to involve the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which can bind to cellular ...