英文名 5-amino-4-methyl-1H-pyridin-2-one 英文别名 更多 5-AMINO-4-METHYLPYRIDIN-2-OL物理化学性质 分子式 C6H8N2O 分子量 124.14100 精确质量 124.06400 PSA 58.88000 LogP 0.84670 5-AMINO-4-METHYLPYRI;5-AMINO-4-METHYLPYRI;946826-32-0; 公司简介 湖北惠择普医药科技有限公司专业从事中间体研发定制、...
1-Amino-5-methyl-1H-pyridin-2-one 1-amino-5-methyl-1H-pyridin-2-one物理化学性质 [ 分子式 ]: C6H8N2O [ 分子量 ]: 124.14100 [ 精确质量 ]: 124.06400 [ PSA ]: 48.02000 [ LogP ]: 0.45170 推荐生产厂家/供应商: 暂无推荐供应商。请联系客服获知如何成为推荐供应商。
英文名称 1H-Isoindol-1-one, 7-[[6-[(dimethylamino)methyl]-5-[(3S)-tetrahydro-3-furanyl]-2-pyridinyl]amino]-4-(7-fluoroimidazo[1,2-a]pyridin-3-yl)-2,3-dihydro- 英文同义词 1H-Isoindol-1-one, 7-[[6-[(dimethylamino)methyl]-5-[(3S)-tetrahydro-3-furanyl]-2-pyridinyl]amino]-4-(...
中文名称:(S)-5-bromo-1-methyl-3-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one 英文名称:(S)-5-bromo-1-methyl-3-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)pyridin-2(1H)-one CAS号:1433849-77-4 分子式:C19H24BrN5...
英文名:6-amino-5-[(6-amino-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(pyridin-3-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 中文名: CBNumber:CB11925145 分子式:C14H13N7O2S2 分子量:375.42872 MOL File:496970-51-5.mol 6-amino-5-[(6-amino-4-oxo-2-thioxo-1,2,3...
生化机理胰岛素受体(IR)和胰岛素样生长因子-1受体(IGF1R)的双重抑制剂(IC50分别为73和100 nM)。抑制受体自身磷酸化以及下游的MEK1 / 2和Akt信号传导。诱导ML-1细胞中G1逮捕和凋亡;它还抑制多种肿瘤类型的细胞增殖。通过减弱表达IGF1R的MCF10A细胞中SnailmRNA的表达来逆转EMT。
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH : 8-(((1R,2R,3R,5S)-2-(2-(4,4-difluorocyclohexyl)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one 来自 Semantic Scholar 喜欢 0 阅读量: 23 作者: C. Chung ...
Here we describe the discovery of a series of 1,3,5-triaryl-1H-pyridin-2-one derivatives as noncompetitive antagonists of AMPA-type ionotropic glutamate receptors. The structure-activity relationships for this series of compounds were investigated by manipulating individual aromatic rings located at ...
4-(4-acryloyl-3,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one Synonyms Pyrido[2,3-d]pyrimidin-2(1H)-one, 7-(2-amino-6-fluorophenyl)-4-[(2S,5R)-2,5-dimethyl-4-(1-oxo-2-propen-1-yl)...
Example 2 Preparation of 4-amino-5-methyl-1H-pyridin-2-One (I) A pressure reactor was charged with 4.0 g of the title compound from Example 1 (compound 2) in 40 ml of methanol and 12.5 g of potassium hydroxide (KOH) was added. This was then heated to 180° C. for 16 hours (ris...