[2] Guedan, et al. Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI insight, 2018.[3] Ying Wang, et al. Combined 4-1BB and ICOS co-stimulation improves anti-tumor efficacy and persistence of dual anti-CD19/CD20 chimeric antigen receptor T cells. Cytotherapy, ...
[2]陈捷(综述), 王兰兰(审校). 共刺激分子4-1BB在T细胞活化效应中的作用[J]. 四川医学, 2006. [3]Engineered T cells: The promise and challenges of cancer immunotherapy[J]. Nature reviews. Cancer, 2016, 16(9):566-...
1. CD137 + T-Cells: Protagonists of the Immunotherapy Revolution.Cancers (Basel). 2021 Jan 26;13(3):456. 2.An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer. Int JMol Sci. 2019 Apr; 20(8): 1822. 3.Immunotherapy targeting 4-1BB...
1. CD137 + T-Cells: Protagonists of the Immunotherapy Revolution.Cancers (Basel). 2021 Jan 26;13(3):456. 2.An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer. Int JMol Sci. 2019 Apr; 20(8): 1822. 3.Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, ...
[3]Engineered T cells: The promise and challenges of cancer immunotherapy[J]. Nature reviews. Cancer, 2016, 16(9):566-581. [4] Chester C , Sanmamed M F , Wang J , et al. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies[J]. Blood, 2017:...
4-1BB作为共刺激因子结构域(co-stimulatory domains,CD)被广泛用于CAR-T细胞治疗。 CAR-T(嵌合抗原受体T)细胞,具有针对癌细胞的定向特异性,是一种很有前景的治疗癌症的方法。目前全球已有6款CAR-T产品上市。4-1BB广泛应用于CAR-T产品的结构设计,诺华的Kymriah的共刺激结构域是4-1BB。作为CAR-T细胞的胞内共刺...
Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol. 2011 Jul;8(4):281-4. Bartkowiak T, Curran MA. 4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity. Front Oncol. 2015 Jun 8;5:117. Chester C, Sanmamed MF, Wang J, Melero I. Immunotherapy targeting 4-...
Originally discovered as a T cell-activating molecule, 4-1BB (CD137) is now also recognized as an activator of non-T cells, thus imparting a new dimension to its potential in vivo effects. 4-1BB expression is seen on a variety of non-T cells including activated dendritic cells (DCs),...
细胞等。当4-1BB与4-1BBL或抗体激动剂结合，共刺激信号可促进T细胞的增殖和活化，并抑制活化诱导的细胞凋亡，进而增强T细胞的免疫杀伤功能。同时，诱导单核细胞等活化，促进细胞因子的分泌，使单核细胞、树突状细胞等在免疫调节中发挥作用。4-1BB/4-1BBL途径在T细胞活化中的作用 （Adam T C Cheuk, et al. ...
4.Milone MC, Fish JD, Carpenito C, Carroll RG, Binder GK, et al. 2009. Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol. Ther. 17:1453–64 ...