报告显示,4因子凝血酶原复合物(4F-PCC)对血液制品消耗有有益影响。2023年4月,发表在《JAMA》的一项双盲、随机、安慰剂对照优效性研究,不支持在有大量输血风险的患者中系统使用4F-PCC。 目的:探讨4F-PCC给药治疗有大量输血风险患者的有效性和安全性。 设计、地点和受试者:2017年12月29日至2021年8月31日,在法...
Julien Pottecher, MD, PhD; Tobias Gauss, MD; Laurent Zieleskiewicz, MD, PhD; Pierre Bouzat, MD, PhD JAMA Network Open Key Points Question Does 4-factor prothrombin complex concentrate (4F-PCC) reduce 24-hour blood product consumption in patients with trauma at risk of massive transfusion?
TraumaOBJECTIVE: Direct factor Xa inhibitors rivaroxaban and apixaban are efficacious alternatives to warfarin and confer a lower risk of spontaneous intracranial hemorrhage (ICH); however, they lack a validated reversal strategy. We evaluated the efficacy and safety of 4-factor prothrombin complex ...
Use of Andexanet Alfa for Factor Xa Inhibitor Reversal in US Verified Trauma Centers: A National Survey: of new medications including a lack of grade 1A evidence supporting the use of prothrombin complex concentrate (PCC) versus andexanet alfa and cost. To... C Fasanya,A Arrillaga,C Caro...
Those results suggest that the AQP4-mediated removal of Tau from the glymphatic system is essential for limiting secondary neuronal damage after trauma. 4.4. Alzheimer's disease (AD) AD is common dementia in the elderly, accounting for about 50–70% of dementia in the elderly(Eratne et al.,...
fibrinogen (pdhFib) (200mg/kg), activated prothrombin complex concentrate (aPCC, 40IU/kg), a three-factor combination intended as a minimal PCC (8mg/... KM Hansson,KJ Johansson,C Wingren,... - 《Blood Coagulation & Fibrinolysis》 被引量: 0发表: 2017年 Efficacy of fibrinogen and prothrom...
Traumaheadcritical care transportemergency care systemsremote and rural medicineprehospital careremote and rural medicineINTRODUCTION: Prothrombin complex concentrates (PCCs) are recommended as first-line treatment for acquired or congenital factor II, VII, IX and X deficiencies in situations of major ...
Effect of coagulation factor concentrate administration on ROTEM® parameters in major trauma Background Purified coagulation factor concentrates, such as fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC) are increasingly used as... M Ponschab,W Voelckel,M Pavelka,... - 《Scandi...