648: 4-FACTOR PCC DOSING FOR URGENT ANTICOAGULATION REVERSAL IN PATIENTS WITH OBESITYdoi:10.1097/01.ccm.0000808916.26196.6cElaina EtterLindsey LindseyMarjorie CurryChristopher MorrisonKatleen ChesterOvid Technologies (Wolters Kluwer Health)Critical Care Medicine...
在接受华法林相关出血逆转治疗的一个大型、种族多样的成人队列中,与血浆治疗相比,接受4F-PCC与45天的血栓栓塞事件风险无关。 References 1.R Sarode, TJ Milling, MA Refaai, A Mangione, A Schneider, BL Durn.Efficacy and safety...
Dosing of 4-factor prothrombin complex concentrate (4FPCC) in warfarin treated patients generally utilizes international normalized ratio (INR) and patient weight. The recommended maximum dosing for all INR categories is capped at 100 kg weight. Whether this affects INR reversal is unknown. Furthermor...
1, such as neratinib, human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) inhibitor; lapatinib, EGFR and receptor tyrosine-protein kinase ERBB-2 inhibitor; fulvestrant, estrogen receptor (ER) antagonist; exemestane, aromatase inhibitor; ribociclib and ...
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However, in other studies, the decrease in Mwand Mnwas not accompanied by an increase in Ð for copolymers with 4HB synthesized byCupriavidussp. andDelftia acidovorans[15,38,64,65,66]. Apparently, the content of 4HB in the copolymer cannot be the main factor affecting the molecular weigh...
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The PITCH study was designed to evaluate clinical and neuro-radiographic outcomes of 4F-PCC in ICH patients on factor Xa inhibitors both within and after 24 hours. Methods: We conducted a retrospective observational study of adult patients with ICH on factor Xa inhibitors who received 4F-PCC ...
The package insert of 4-factor prothrombin complex concentrate (4F-PCC) contains specific dosing recommendations stating to determine the patients dose based on their INR and weight, capping the weight at 100?kg. However, the mean body mass index (BMI) in the 4F-PCC U.S. approval study was...
The package insert of 4-factor prothrombin complex concentrate (4F-PCC) contains specific dosing recommendations stating to determine the patients dose based on their INR and weight, capping the weight at 100kg. However, the mean body mass index (BMI) in the 4F-PCC U.S. approval study was ...