(gamma-aminobutyric acid,GABA)的含量.结果:GS-MS分析出β-蒎烯,桉油精,方樟醇等10种有效成分,进一步分析出治疗失眠的关键靶点有19个,PPI网络提示SLC6A3,GABRA2,GRIA2,GABRA1和GABRA6等可能是苏格木勒-4挥发油抗失眠的核心靶点.GO富集分析中符合P<0.05条件的GO条目54个,KEGG通路富集分析中要求符合P<0.05得到...
(gamma-aminobutyric acid,GABA)的含量.结果:GS-MS分析出β-蒎烯,桉油精,方樟醇等10种有效成分,进一步分析出治疗失眠的关键靶点有19个,PPI网络提示SLC6A3,GABRA2,GRIA2,GABRA1和GABRA6等可能是苏格木勒-4挥发油抗失眠的核心靶点.GO富集分析中符合P<0.05条件的GO条目54个,KEGG通路富集分析中要求符合P<0.05得到...
While serine, leucine, phenylalanine, lysine, tyrosine, histidine, isoleucine, proline, valine, phenylalanine and γ-aminobutyric acid contents increased but N-acetyl-L-glutamic acid, reduced glutathione, N-α-acetyl-L-arginine decreased in the early stage of withering (0-12 h). The contents of...
We found differences in ubiquitin-mediated proteolysis via KEGG pathway enrichment, included the E3 ubiquitin ligase Nedd4l that was found to be upregulated in SS mice (Fig. 3a, Supplementary Table 1). We further verified the protein and mRNA levels of Nedd4l in the mPFC samples of CSDS ...
phenylalanineandγ-aminobutyric acid contentsincreased butN-acetyl-L-glutamic acid, reduced glutathione,N-α-acetyl-L-arginine decreased in the early stage of withering(0-12 h).The contentsof glutamic acid and acetylglycine decreased in the later s...
receptor interaction gastric acid secretion folate biosynthesis estrogen signaling pathway dopaminergic synapse cocaine addiction amphetamine addiction alcoholism 0.025 −lgP 7 5 3 基因数 2 4 6 8 10 12 0.075 0.125 rich factor 图 9 模型组 (A) 和 DGMI 组 (B) DEGs 的 KEGG 通路富集分析气泡图 ...
Via the KEGG pathway analysis of the lncRNAs, we found that 21 pathways (Q value ≤ 0.05) were enriched. These included metabolic pathways (618) and metabolism of ascorbate and aldarate (44), caffeine (26), xenobiotics, and drug metabolism by P450s (113) or other enzymes (76), such as...
molecules Article Synthesis, Characterization, and Anticancer Activities Evaluation of Compounds Derived from 3,4-Dihydropyrimidin-2(1H)-one Ye Liu 1, Jiaqi Liu 1, Renmei Zhang 1, Yan Guo 1, Hongbo Wang 1, Qingguo Meng 1, Yuan Sun 2 and Zongliang Liu 1,* 1 School of Pharmacy, Key ...
Results . Twelve compounds interacted with 49 targets, of which top three targets were gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), prostaglandin G/H synthase 2 (PGHS-2), and sodium-dependent noradrenaline transporter. Interestingly, these targets were highly associated with depression,...
Cd-induced differentially accumulated metabolites in the roots. The heat maps of Cd-induced DAMs content (Z-score value) in the roots among different treatments (a). Top 20 KEGG enrichment of DAMs (b). Sankey diagram of DAMs among various treatments compared with the control (c). The signif...