INHIBITORS OF 17Beta-HSD1, 17Beta-HSD3 AND 17Beta-HSD10The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSDl inhibitors include ...
Inhibitors of 17beta-hsd1, 17beta-hsd3 and 17beta-hsd10Inhibitors of 17beta-hsd1, 17beta-hsd3 and 17beta-hsd10., , The Patent Description & Claims data below is from USPTO Patent Application 20140088053, Inhibitors of 17beta-hsd1, 17beta-hsd3 and 17beta-hsd10.UniversitÉ Laval...
Compounds of formula (I) wherein variable groups are defined within; their use in the inhibition of 11.beta.HSD1, processes for making them and pharmaceutical compositions comprising them are described.doi:CA2668006 A1MCCOULL, WILLIAMPACKER, MARTIN...
The use of compounds of formula (I): wherein variable groups are defined within; in the manufacture of medicaments for use in the inhibition of 11尾HSD1, processes for making them, certain compounds within the definition of the formula (I) and pharmaceutical compositions comprising them are ...
[3.1.1] hept-6 yl)-[5-(1H- pyrazoles -4-yl)-thiophene -3-yl]-methanone, and 4,4- diyls instead of piperidin-1-yl)-especially inhibit 11 beta-hydroxysteroid dehydrogenase Class1 (11 尾-HSD1) following public formula (I) [5-(1H- pyrazoles -4-yl)-thiophene -3-yl]-methanone ...
The use of compounds of formula (I): wherein variable groups are defined within; in the manufacture of medicaments for use in the inhibition of 11betaHSD1, processes for making them, certain compounds within the definition of the formula (I) and pharmaceutical compositions comprising them are ...
BARTON, PETER, JOHNBUTLIN, ROGER, JOHNPEASE, JANET, ELIZABETHBARTON, JOHN P,et al. N-Aeylated-3-(Benzoyl)-Pyrrolidines as 11-Beta-HSD1 Inhibitors Useful for the Treatment of Meta- bolic Disorders [P]. U. S. :2005047250,26 May 2005....
4,5-Dicyclopropyl-1-methyl-2-phenyl-1,2-dihydro-pyrazol-3-one; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1); 4-Cyclopropyl-5-(2,2-difluoro-cyclopropyl)-1-methyl-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-pyrazol-3-one;
[3.1.1] hept-6-yl)-[]-thiophen-3-yl 5- (1H-pyrazol-4-yl) ketone, 4, disubstituted piperidin-1-yl)-[]-thiophen-3-yl 5- (1H-pyrazol-4-yl) ketones compound for indicating following formula, for example, especially inhibiting 11 尾-hydroxysteroid dehydrogenase type 1s (11 尾-HSD1). ...
Pyrrolidines 3 - (benzoyl) - N - aciladas, as inhibitors of 11 beta HSD1, useful in the treatment of Metabolic Disorders13. Claim 13: responsive compound (1),- 1-1-1-1-1- 11-1-1-11, 11 11 11 11 1 - and C 0-4 pitch-z -;In this case, R1 can be selectively substituted ...