Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate. We have previously shown that PC is overexpressed in highly invasive cancer cell lines where it supports biosynthesis during rapid cell growth. Here, we show that miR-143-3p suppresses the expression of...
2.6.1.15l -glutamine:pyruvate aminotransferaseglutamine-pyruvate transaminaseaminotransferase, glutamine-keto acidγ-glutaminyltransferaseglutaminase IIglutamine transaminaseglutamine transaminase Lglutamine- α -keto acid transamidaseglutamine- α -keto acid transaminaseglutamine-keto acid aminotransferaseglutamine-oxo...
Additionally, qRT-PCR and Western blot experiments were conducted to measure the expression of circ_0000418, microRNA-409-3p (miR-409-3p) and pyruvate dehydrogenase kinase 1 ( PDK1 ) in glioma tissues/cells. Cell growth and cell cycle distribution were monitored using CCK-8 assay, BrdU assay...
The expression of a target gene of miR-363-3p, pyruvate dehydrogenase B (PDHB), was determined by Western blot. The level of miR-363-3p was increased or decreased by transfected with miR-363-3p mimic or miR-363-3p inhibitor, respectively. The impact of miR-363-3p on cell growth, ...
miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1doi:10.1002/iub.2212PYRUVATE dehydrogenase kinaseKREBS cycleGENE expression profilingCANCER cell growthOXIDATIVE phosphorylation...
miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1gliomamiR-128-3pPDK1Warburg effectGlioma, like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect, which is a dominant...