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testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-...
Spheroids are simple, widely used multicellular 3D models that form due to the tendency of adherent cells to aggregate.
Spheroids are simple, widely used multicellular 3D cell culture models that form due to the tendency of adherent cells to aggregate in stem cell research, tumor biology, and immune oncology.
Multicellular tumor spheroids: A relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines. Polym. Chem.2017. Nanomaterials (ISSN 2079-4991; IF 4.324)是一个与纳米材料研究相关的国际性开放获取期刊。目前已被SCIE、Scopus 等重要数据库收录。Nanomaterials 期刊采用单盲同行评审,一般...
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(2010) Multicellular tumor spheroids: an underestimated tool is catching up again. Biotechnol 148(1): 3-1. Gaskell H et al. (2016) Characterization of a functional C3A liver spheroid model. Toxicol Res (Camb) 5(4): 1053-65. Wenzel C et al. (2014) D high-content ...
Taking into consideration that these promising results on 2D monolayer cell cultures might not translate into similar results in animal models, we developed 3D multicellular tumour spheroids (MCs) as an intermediate step to bridge the gap between 2-D cell experiments and in-vivo studies. TMNPs ...
3D cell culture methods — and multicellular tumorspheroids(MCTS), in particular — are quickly becoming a valuable tool for studying the tumor microenvironment incancer research. Cancer scientists are creating increasingly complex tumor models that more ...