3D Immunocompetent Organ‐on‐a‐Chip Modelsextracellular matricesimmune cellsimmunocompetencymicroenvironmentsorgans‐on‐chipsdoi:10.1002/smtd.202000235Sushila MaharjanDivision of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USABerivan ...
Ingber, Microfluidic organ-on-a-chip models of human intestine, 5(4) (2018) 659-668. 个性化定制您的微流控肠芯片 该实验套装包含的错流膜由可以采用亲水或不亲水的COP或PS(聚苯乙烯)材料制成。您可以根据具体的应用,选择两种不同的孔径:0.2μm或8μm。膜片也是支持定制的。 微流体肠芯片实验套装内的...
et al. A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396 (2019). Article CAS PubMed Google Scholar Tan, H.-Y. et al. A multi-chamber microfluidic intestinal barrier model using Caco-2 ...
Microfluidic models represent a new frontier for studying the complex interactions occurring within organ microenvironments in both physiologic and pathologic conditions16, 17. The recent advances in both cell biology and microengineering have allowed the development of the innovative organ-on-chip approach...
extracellular matrix 3D models tumor on a chip Towards Biologically Relevant Tumor Models The composition of the tumor microenvironment (TME, see Glossary) and tumor stromal interactions are major factors that aggravate tumor growth and metastasis, leading to poor clinical outcomes [1., 2., 3., 4...
Free multimedia tools Contact contact@elveflow.com +33(0).184.163.807 +1(414)-406-4343Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip....
Whole blood, with all its immunocompetent cells, represents a robust and complex immunological system involved in sepsis pathogenesis [25]. Literature reports different gene expressions, depending on the subpopulation of immunocompetent cells [26]. Practically, no investigation has been performed that ...
Engineered models such as bone-on-a-chip, extramedullary bone, and bioreactors are presently used to model cellular crosstalk and bone–tumor cell interactions, but fall short of providing a bone-biomimetic microenvironment. Three-dimensional bioprinting allows for the deposition o...
Each of these 3D models, ranging from mono- typic cultures to immunocompetent co-cultures, repre- sents a physiologically relevant assay system in its own right for use in such studies. Future clinical applications Infectious diseases continue to rank among the lead- ing causes of death world...
In this Review, we examine biofabrication strategies for the construction of functional tissue replacements and organ models, focusing on the development of biomaterials, such as supramolecular and photosensitive materials, that can be processed using biofabrication techniques. We highlight bioprin...