3b-羟基类固醇脱氢酶缺乏症的英文名字是3b-hydroxysteroid dehydrogenase deficiency。基因解码表明:佳学基因采用基因解码表明,3b-羟基类固醇脱氢酶缺乏症是由基因突变引起的。这种疾病是由于3b-羟基类固醇脱氢酶基因中的突变导致酶的功能缺陷或有效缺失,从而影响体内激素的合成和代谢。这种基因突变可以是遗传的,也可以是新生...
3b-羟基类固醇脱氢酶缺乏症的英文名字是3b-hydroxysteroid dehydrogenase deficiency。基因解码表明:3b-羟基类固醇脱氢酶缺乏症是一种遗传性疾病,与基因突变密切相关。 3b-羟基类固醇脱氢酶是一种酶,参与胆固醇合成途径中的一步反应。该酶由HSD3B2基因编码。当HSD3B2基因发生突变时,会导致3b-羟基类固醇脱氢酶的功能受损...
3β-hydroxysteroid dehydrogenase (3β-HSD) 是HSD3B基因的產物,可將受質分子△5的氫原子經由同素構作用轉移至△4.固醇荷爾蒙為膽固醇衍生物,當P450scc將膽固醇轉換成孕烯醇酮,後續反應幾乎要3β-HSD作用才能產生最終產物.脊椎動物體內存在多種HSD3B基因,並具有組織表現專一性.已知人體中有HSD3B1,HSD3B2與五個...
(3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (Trophoblast antigen FDO161G) [Includes/ 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 111145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5331) (...
The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- ...
In addition, 4 other enzymes important to steroid hormone biosynthesis, 11 beta-hydroxylase, 17 alpha-hydroxylase, side-chain cleavage enzyme P450, and 3 beta-hydroxysteroid dehydrogenase, were expressed in E. coli, but none of them gave positive autoantibody reactions by Western blot assays, even...
UV 照射或情绪压力等应激上调11β -羟基类固醇脱氢酶1 型(11β -hydroxysteroid dehydrogenase type 1,11β -HSD1)的表达,11β -HSD1 将无活性可的松转化为生物活性皮质醇,导致角质形成细胞生长抑制、基质金属蛋白酶活化、NF - κB 激活等,使皮肤伤口愈...
Compared with the controls, PCOS patients showed significantly higher levels of 3β-hydroxysteroid dehydrogenase1-2 (3β-HSD1-2), aldo-keto reductase 1C 1–3 (AKR1C1-3) and leptin, but lower level of P450 aromatase and 5α-reductase 1. Interestingly, leptin was positively correlated to ...
Blocking BRE expression in Leydig cells inhibits steroidogenesis by down-regulating 3β-hydroxysteroid dehydrogenase Conversion of cholesterol to biologically active steroids is a multi-step enzymatic process. Along with some important enzymes, like cholesterol side-chain... J,Miao,K-W,... - 《Journal...
目的:评估11β-羟基类固醇脱氢酶1(11β-hydroxysteroid dehydrogenase type 1,11β-HSD1)抑制剂BVT.2733对肥胖小鼠骨骼肌,肝脏,肾脏,心肌和脾脏中代谢和炎症相关基因... 尹立平,王龙,吕珊,... - 《南京医科大学学报(自然科学版)》 2019年39卷12期 1716-1722页 ISTIC PKU CSCD CA 被引量: 0发表: 2020年 ...