PURPOSE: To provide a method for producing (R)-(-)-4-cyano-3-hydroxylatic acid t-butyl ester useful as an intermediate for medicines in high optical purity using (S)-(-)-4-halogeno-3-hydroxylactic acid t-butyl ester readily available from diketene as a raw material.三橋 茂...
(-)-3-hydroxybutyric acid as the sole carbon source and an antibiotic which destroys active or growing cells. The surviving, resting or non-growing, cells which do not form the enzyme 3-hydroxybutyric acid dehydrogenase (=EC 1.1.1.30; see E. T. Barman, Enzyme Handbook, Springer-Verlag, ...
The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention pr
improved process for the synthesis of protected -3,4-dihydroxybutyric acid esters (s) process.The invention herein refers to an improved process for ... T Jacks,D Butler 被引量: 0发表: 1997年 Modified Preparation of (2R)-2-tert-Butyl-6-methyl-4H-1,3-dioxin-4-one; a Chiral Acetylace...
as ethyl acetate, toluene, diisopropyl ether or methylene chloride and then washed with water and the solvent is distilled off and the resultant residue is recrystallized with toluene, ethyl acetate, ethanol, etc., to obtain (R)-(-)-4-cyano-3-hydroxylactic acid t-butyl ester of formula II...
butyl ( S )-3-hydroxybutyrate (2) via kinetic resolution of (±)-1 With toluene as the reaction medium, the enantioselection was found to be excellent for 2 and moderate for the resolved acid (1).doi:10.1007/BF00128313S. Chattopadhyay...
PREPARATION:A compound shown by formula II and an alcohol shown by the formula ROH are subjected to ester exchange reaction by using an ammonium salt of sulfonic acid derivative shown by formula III (R<1> is lower alkyl, phenyl, etc.; R<2> to R<4> are lower alkyl or R<2> to R<...