Among the four common genes for echinomycin chromophore biosynthesis, the putative function (L-tryptophan 2,3-dioxygenase) of the remaining gene ecm11 sug- gested that 3-hydroxy-L-kynurenine (5) is a common intermediate in the chromophore biosynthesis. Feeding experiments of (2S,3R)-(6¢-...
Here, we report experiments involving incorporation of a putative advanced precursor, (2S, 3R)-[6′-2H]-3-hydroxy-L-kynurenine, and functional analysis of the enzymes Swb1 and Swb2 responsible for late-stage biosynthesis of HQA. On the basis of these experimental results, we propose ...
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis Kynurenine 3-mono-oxygenase, one of the key enzymes of the "kynurenine pathway", catalyses the formation of 3-hydroxykynurenine and may direct the ...